The paper presents a model predictive control method for continuous-time systems based on subspace identification. It’s developed by reformulating the continuous-time systems using Laguerre filters to obtain the subspace prediction output. Then, the subspace predictors are derived by QR decomposition from input-output and Laguerre matrices. The subspace predictive controller is designed with th...

The possibility of applying membrane distillation to support the fermentation process was investigated. The capillary polypropylene membranes were assembled in the membrane modules. The studies were carried out using the standard solutions containing the compounds frequently occurring in the broths such as ethanol, citric, acetic and lactic acids, glycerol and 1,3-propanediol. The performance o...

Bioprocess scale-down simulators are used to investigate the phenomena occurring in industrial scale cultivations. The aim is to simulate the large-scale conditions, characterized by long mixing times introducing local gradients into the bioreactor, in laboratory scale bioreactor. We have expanded the current physiological knowledge about the consequences of such cultivation conditions from wel...

Hydrogen may be considered a potential fuel for the future since it is carbon-free and oxidized to water as a combustion product. Bioconversion of synthesis gas (syngas) to hydrogen was demonstrated in continuous stirred tank bioreactor (CSTBR) utilizing acetate as a carbon source. An anaerobic photosynthetic bacterium, Rhodospirillum rubrum catalyzed water-gas shift reaction which was applied ...

The effect of shear stress on the production of a high viscosity polysaccharide, methylan, from methanol by Methylobacterium organophilum was investigated by using a multidisk mixer. It was observed in the multidisk mixer with defined shear stresses that the specific production rate of methylan increased gradually with increasing shear stress up to 30 Pa, and the production rate was constant be...

In the production of biofuel from lignocellulose biomass, particularly in the case of consolidated bioprocessing where the saccharification and fermentation steps take place within the same bioreactor, many compounds may be present that could affect the enzymes within such a bioreactor. This study examined the effect of ethanol, butanol, propanol, lignin, -coumaric acid, and gallic acid on the...

Most native strains efficiently ferment individual preferential sugars but not the mixed to bioethanol. Therefore, a two-stage sequential fermentation was carried out in single bioreactor vessel convert sugars, mixture of synthetic glucose and xylose, into bioethanol using Z. mobilis P. stipitis at stage-1 (glucose fermentation) stage-2 (xylose fermentation), respectively. A total 160 g/L (100 ...

In this article a hydrodynamic and rheological analysis of a continuous airlift bioreactor with high-cell-density system is presented. A highly flocculating recombinant strain of Sacharomyces cerevisiae containing genes for lactose transport (lactose permease) and hydrolysis (beta-galactosidase) was exploited to ferment lactose from cheese whey to ethanol. The magnetic particle-tracer method wa...

Electro fermentation is a novel approach for increasing the production of microbial products. The article is a summary of the generally used fermenters and the moderations that can be done to improve. The technique of electro fermentation is well known, but not used to its fullest potentials. Thus the study shows what are the advantages of using electro fermentation. INTRODUCTION A bioreactor p...

Introduction The production of protein-based medical agents, like monoclonal antibodies (Mabs), by biotechnological processes requires a comprehensive quality control. The pharmaceutical industry and national health authorities support the complete characterization of therapeutic proteins to increase the quality and safety. During numerous and different production steps like fermentation, purif...