OBJECTIVES Evaluation of a wide variety of pyridine N-oxide derivatives on their inhibitory activity against feline coronavirus (FIPV strain) and human SARS-CoV (Frankfurt strain-1) in cell culture. METHODS FIPV and SARS-CoV were exposed to confluent Crandel feline kidney (CRFK) and simian kidney (Vero) cell cultures in the presence of serial concentrations of the test compounds. The anti-cyt...

Peritonitis is inflammation of the peritoneal cavity. It may be primary (e.g., hematogenous infection of the peritoneum as in feline infectious peritonitis) or secondary (i.e., resulting from chemical or septic contamination of the peritoneal cavity) and may be generalized (i.e., diffuse) or localized (i.e., only a small portion of the abdomen is involved). Chemical peritonitis is caused by the...

Incidences of major feline viral diseases provide basic information for preventing disease in cats. Despite the growing interest diseases, sero-surveillances have been lacking. In this study, we analyzed diagnoses and conducted a sero surveillance panleukopenia virus (FPV), calicivirus (FCV), herpesvirus-1 (FHV-1), infectious peritonitis (FIPV) Korean Of 204 confirmed cases since 2015, numbers ...

Formation of the coronavirus replication-transcription complex involves the synthesis of large polyprotein precursors that are extensively processed by virus-encoded cysteine proteases. In this study, the coding sequence of the feline infectious peritonitis virus (FIPV) main protease, 3CL(pro), was determined. Comparative sequence analyses revealed that FIPV 3CL(pro) and other coronavirus main ...