BACKGROUND AND AIMS Mucosal healing is an important predictor of disease-related outcome in patients with inflammatory bowel disease (IBD) patients, including those in clinical remission. However, colonoscopy is an invasive procedure and many patients decline repeated endoscopic examinations. We aimed to assess whether noninvasive biomarkers could accurately detect endoscopic mucosal inflammato...

Background and Aim. In the inflammatory bowel diseases (IBDs), many symptoms are similar to the functional disorder irritable bowel syndrome (IBS). A challenge is thus to distinguish symptoms of IBD from IBS. The aim of this study was to investigate the levels of calprotectin in IBS-positive IBD patients in remission. Methods. Remission was defined as a simple clinical colitis activity index (S...

BACKGROUND Iron is essential for the growth and virulence of many pathogenic enterobacteria, whereas beneficial barrier bacteria, such as lactobacilli, do not require iron. Thus, increasing colonic iron could select gut microbiota for humans that are unfavorable to the host. OBJECTIVE The objective was to determine the effect of iron fortification on gut microbiota and gut inflammation in Afr...

BACKGROUND The pancreatitis-associated protein (PAP) is increased in the serum of active inflammatory bowel disease (IBD) patients and its levels seem to be correlated with disease activity. Our aim was to evaluate the usefulness of serum and fecal PAP measurements to predict relapse in patients with inactive IBD. MATERIALS AND METHODS We undertook a 12-month prospective study that included 6...

Abstract Calprotectin is a positive acute-phase protein participating in innate immune responses and inflammatory processes. This produced mainly neutrophils, which infiltrate inflamed tissues then increase the level of calprotectin plasma, urine, or body secretions. Its measurement used diagnosis many diseases gastrointestinal tract. Here, we reviewed studies evaluating utility when patient su...

Abstract Context Calprotectin is a cytoplasmic-protein that released upon neutrophilic activation. Measuring fecal-calprotectin (FC) used for monitoring inflammatory bowel disease activity and distinguishing it from irritable syndrome. However, its utility in other types of colitis has not been well-investigated. Design Cases collagenous-colitis (CC) lymphocytic-colitis (LC) between 2015 2020 w...

BACKGROUND The World Health Organization recommends exclusive breastfeeding until 6 months followed by introduction of iron-rich complementary foods (CFs). The aim of this study was to determine the impact of different iron-rich CFs on infant gut inflammation and microbiota. METHODS Eighty-seven exclusively breastfed infants were randomly assigned to receive one of the following as their firs...

BACKGROUND Fecal calprotectin (FC) is an established simple biomarker of gut inflammation. To examine a possible relationship between linear growth and gut inflammation, we compared fecal calprotectin levels in 6 month old infants from poor rural vs affluent urban families. METHODS The project was a cross-sectional comparison of FC from rural and urban populations in China. The relationship b...

In the course of Inflammatory Bowel Disease (IBD), the possibility of an increase of pancreatic enzymes has been described, almost always justified with their release by the inflamed bowel. Unusually an acute pancreatitis presents itself as a pathology associated to the IBD, probably with a common pathogenetic mechanism. We report the case of a 25 year old man with fever, epigastralgia and a mi...