Diffusion-weighted imaging estimates of apparent diffusion coefficient (ADC) have shown sensitivity to brain tumor cellularity as well as response to therapy. Functional diffusion maps (fDMs) exploit these principles by examining voxelwise changes in ADC within the same patient over time. Currently, the fDM technique involves linear image registration of ADC maps from subsequent follow-up times...

MOTIVATION In eukaryotic cells, alternative splicing expands the diversity of RNA transcripts and plays an important role in tissue-specific differentiation, and can be misregulated in disease. To understand these processes, there is a great need for methods to detect differential transcription between samples. Our focus is on samples observed using short-read RNA sequencing (RNA-seq). METHOD...

PURPOSE It is well known that the dopaminergic signaling pathway plays a pivotal role in the control of axial elongation. Much research has shown that retinal dopamine (DA) is decreased in experimental myopia, but the exact alteration in DA quantity underlying the myopia model induced by flickering light (FL) has not yet been fully elucidated. Therefore, in this study, we first attempted to pro...

Introduction Measuring intramyocellular lipids (IMCL) in 1H MRS has been popular for its relation to insulin sensitivity, diabetes and obesity (1). However, quantification of IMCLs are often difficult because they are strongly overlapped with extramyocellular lipids (EMCL)(2, 3). The time domain algorithms offer many advantages for the quantification for separating IMCL and EMCL (1,4). First, t...

PURPOSE Atropine, pirenzepine, and himbacine prevent form-deprivation myopia (FDM) when administered intravitreously. The mechanisms and sites of action of these drugs against myopia are not clear. To shed further light on whether this mechanism is muscarinic, several other muscarinic antagonists were tested. METHODS Various concentrations of atropine, pirenzepine, dexetimide, scopolamine, tr...

Free Download Manager (FDM) is one of the most popular download managers due to its free availability, high download speed and versatility. It contains a lot of information that is of potential evidentiary value even if a user deletes web browser history, cookies and temporary internet files. This software records download activities across multiple files saved with .SAV extensions in the User ...

The collapse temperature (Tc) and the glass transition temperature of freeze-concentrated solutions (Tg') as well as the crystallization behavior of excipients are important physicochemical characteristics which guide the cycle development in freeze-drying. The most frequently used methods to determine these values are differential scanning calorimetry (DSC) and freeze-drying microscopy (FDM). ...

Cold dark matter (CDM) is a well established paradigm to describe cosmological structure formation, and works extraordinarily well on large, linear, scales. Progressing further in dark matter physics requires being able to understand structure formation in the non-linear regime, both for CDM and its alternatives. This short note describes a calculation, and accompanying code, WARMANDFUZZY, inco...

A numerical explicit method to evaluates transient solutions of linear partial differential inhomogeneous equation with constant coefficients is proposed. A general form of the scheme for a specific linear inhomogeneous equation is shown. The method is applied to the wave equation and the diffuse equation and is investigated by simulating simple models. The numerical solutions of the proposed m...

The overexpression of fdm, which encodes the formaldehyde dismutase from Pseudomonas putida F61, resulted in the formation of inclusion bodies made up of aggregated enzyme, leaving little activity in the soluble fraction of the transformant cells. On the other hand, coexpression of groESL along with fdm facilitated in vivo solubilization of the enzyme protein in its active form. When coexpresse...