Focal dermal hypoplasia (FDH) is a rare genetic skin disorder. The inheritance of FDH or Goltz-Gorlin syndrome is X-linked dominant and the disease is associated with a PORCN gene mutation. This gene plays a key role in the Wnt pathway, which has an impact on embryonic development. Every tissue derived from meso- and ectoderm can be affected. Patients suffer from cutaneous, ocular, osseous, ora...

This paper defines the properties of FDT (Flow Dependence Tail set) and FDH (Flow Dependence Head set), and presents two partitioning methods for finding two parallel regions in two-dimensional solution space. One is the region partitioning method by intersection of FDT and FDH. Another is the region partitioning method by two given equations. Both methods show how to determine whether the inte...

The need to adapt Data Envelopment Analysis (DEA) and other frontier models in the context of negative data has been a rather neglected issue in the literature. A recent article in this journal proposed a variation on the directional distance function, a very general distance function that is dual to the profit function, to accommodate the occurrence of negative data. In this contribution, we d...

The relationship between directional derivatives of generalized distance functions and the existence of generalized nearest points in Banach spaces is investigated. Let G be any nonempty closed subset in a compact locally uniformly convex Banach space. It is proved that if the one-sided directional derivative of the generalized distance function associated to G at x equals to 1 or −1, then the ...

In this paper, we follow Kuroiwa’s set approach in set optimization, which proposes to compare values of a set-valued objective map F respect to various set order relations. We introduce a Hausdorff-type distance relative to an ordering cone between two sets in a Banach space and use it to define a directional derivative for F . We show that the distance has nice properties regarding set order ...

Formate dehydrogenases (FDHs) are enzymes that catalyze the formate oxidation to carbon dioxide and that contain either Mo or W in a mononuclear form in the active site. In the present work, the influence of Mo and W salts on the production of FDH by Desulfovibrio alaskensis NCIMB 13491 was studied. Two different FDHs, one containing W (W-FDH) and a second incorporating either Mo or W (Mo/W-FDH...

Focal dermal hypoplasia (FDH) is a rare syndrome of severe developmental anomalies of the tissues and organs derived from ectoderm and mesoderm. Though data have suggested that FDH is an X-linked dominant trait associated with male hemizygote lethality, a hypothesis supported by the observation of three unrelated infants with FDH manifestations and de novo chromosome rearrangements involving Xp...

Section 2 FT-IR spectra of the NG/AuNPs, NG/AuNPs/FDH and NG/AuNPs/laccase Section 3 Control experiments at different electrode. Section 4 CV of the formic acid oxidation Section 5 Polarization curves of the NG/AuNPs/FDH electrode and G/AuNPs/FDH electrode Section 6 Crossover between the bioanode and biocathode Section 7 Dependence of power density on the formic acid concentration for EBFC Sect...

BACKGROUND Goltz syndrome or focal dermal hypoplasia (FDH) is an uncommon multisystem disorder. Herein, we report a typical case of FDH with unilateral ocular, cutaneous and skeletal features. CASE PRESENTATION a 4-year-old girl presented with microphthalmos and iris coloboma of the left eye, facial asymmetry, and a low-set protruding ear. Cutaneous changes included hypopigmented atrophic mac...

NAD(+)-dependent formate dehydrogenase (FDH, EC 1.2.1.2) widely occurs in nature. FDH consists of two identical subunits and contains neither prosthetic groups nor metal ions. This type of FDH was found in different microorganisms (including pathogenic ones), such as bacteria, yeasts, fungi, and plants. As opposed to microbiological FDHs functioning in cytoplasm, plant FDHs localize in mitochon...