Cortisol is a key regulator of the immune system, energy metabolism, and stress, yet its relevance to fatigue experienced by people with relapsing-remitting multiple sclerosis (RRMS) remains uncertain. We examined cortisol secretory activity in RRMS and its association with fatigue severity between-individuals and within-individuals (day-to-day) using a case-control ecological momentary assessm...

OBJECTIVE Fatigue and depression are highly comorbid phenotypes with partially overlapping symptoms. The main aims of the present study are to: (i) identify the risk of current fatigue and depression; (ii) determine if the depression symptoms experienced by individuals who are fatigued (N=766) and non-fatigued (N=1849) are different; and (iii) identify if the fatigue symptoms experienced by dep...

The description of muon propagation through large depths of matter, based on a concept of the correction factor, is proposed. The results of Monte-Carlo calculations of this correction factor are presented. The parametrizations for continuous energy loss coefficients, valid in the broad interval of muon energies, and for the correction factor are given. The concrete calculations for pure water ...

Crack growth analysis has remained one of the challenging problems in the fracture mechanics of structures. On the other hand, the fatigue crack growth is a common phenomenon in the components of structures like airplanes, navies and fluid storages where the fracture due to crack should be considered in the design of these structures. In this paper, the finite volume method (FVM) is extended fo...

It is necessary to manage the fatigue crack growth (FCG) once those cracks are detected during in-service inspections. In this paper, a simulation program (FCG-System) is developed utilizing the commercial software ABAQUS with its object-oriented programming interface to simulate the fatigue crack path and to compute the corresponding fatigue life. In order to apply FCG-System in large-scale ma...

There is evidence that daily negative events at work enhance fatigue. In contrast, positive events may trigger processes that increase, but also processes that decrease, energetic resources. Accordingly, results regarding a main effect of positive events on fatigue have been mixed. However, a clearer pattern between positive events and fatigue can be expected under adverse circumstances (i.e., ...

The Circadian Alertness Simulator (CAS) was developed as a practical tool for assessing the risk of diminished alertness at work. Applications of CAS include assessment of operational fatigue risk, work schedule optimization, and fatigue-related accident investigation. Based on the documented work schedules of employees, sleep and alertness patterns are estimated and a cumulative fatigue score ...

Much of the recent research at the NDE Centre at UCL has revolved round the study of the scattering of thin skin electromagnetic fields by a fatigue crack. The early work concentrated on the perturbations to the surface electric field (ACPD), while the more recent work involved the scattered magnetic field (ACFM). The Centre has recently become involved in a collaborative project, a part of whi...

A flexural model of four-point bending fatigue that has been experimentally validated for human cortical bone under load control was used to determine how load and displacement control testing affects the fatigue behavior of human cortical bone in three-point and symmetric four-point bending. Under load control, it was predicted that three-point bending produced no significant differences in fa...