Dopaminergic signaling is one of the regulatory pathways being investigated for its implication in glucose metabolism. The aim of this study was to determine the effect of cabergoline on biochemical and anthropometric parameters in prediabetes stage (impaired fasting glucose and impaired glucose tolerance). In this double blind, placebo-controlled, pilot study, 27 prediabetic adults were random...

AIM To investigate associations of fasting insulin and glucose levels in serum with hepatocellular carcinoma risk. MATERIALS AND METHODS This hospital based study was carried out using data retrieved from the register maintained in the Department of Biochemistry of the Nepalese Army Institute of Health Sciences, between 1st December, 2011 and 31st June, 2013. The variables collected were age,...

BACKGROUND Patients with heart failure (HF) have higher fasting insulin levels and a higher prevalence of insulin resistance as compared with matched controls. Insulin resistance leads to structural abnormalities in the heart, such as increased left atrial size, left ventricular mass, and alterations in transmitral velocity that can precede the diagnosis of HF. It is not known whether insulin r...

Fasting readily induces hepatic steatosis. Hepatic steatosis is associated with hepatic insulin resistance. The purpose of the present study was to document the effects of 16 h of fasting in wild-type mice on insulin sensitivity in liver and skeletal muscle in relation to 1) tissue accumulation of triglycerides (TGs) and 2) changes in mRNA expression of metabolically relevant genes. Sixteen hou...

OBJECTIVE To assess the utility of HOMA-IR in assessing insulin resistance in patients with polycystic ovary syndrome (PCOS) and compare it with fasting insulin for assessing insulin resistance (IR). STUDY DESIGN Observational study. PLACE AND DURATION OF STUDY Section of Clinical Chemistry, Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi, from Jan...

Infusion of physiological levels of insulin and/or amino acids reproduces the feeding-induced stimulation of muscle protein synthesis in neonates. To determine whether insulin and amino acids independently stimulate skeletal muscle protein synthesis in neonates, insulin secretion was blocked with somatostatin in fasted 7-day-old pigs (n = 8-12/group) while glucose and glucagon were maintained a...

objective: type 2 diabetes is associated with elevated oxidative stress and decline in antioxidant defense. vitamin e supplementation reduces oxidative stress level in diabetic pa-tients. purpose of this study was to evaluate the effect of vitamin e supplementation on glycemic control and lipid profile in type 2 diabetic patients. material and methods: in this study 31 type 2 diabetic patients ...

background: the frequency of sonographic report of liver fat infiltration in asymptomatic person is increasing. the aim of this study was evaluation of liver function and detection of frequency of metabolic syndrome and insulin resistance in asymptomatic persons with fatty liver in sonographic examinations. materials and methods: seventy six patients with fatty liver in sonographic examination ...

OBJECTIVE Circulating leptin levels correlate positively with the degree of obesity and prolonged hyperinsulinaemia increases serum leptin levels. Moreover, insulin secreting beta-cells express functional leptin receptors indicating a functional relationship between leptin and insulin. The aim of this study was to examine the relationship between fasting serum leptin levels and measures of insu...