BACKGROUND The objective of this study was to determine the in vivo pharmacodynamics of glucagon and to test its glycemic effect over days by assessing its time course of activity and potency in a type 1 diabetic swine model. METHODS Individual experiments were conducted in different pigs using glucagon preparations that were reconstituted on different days and stored at room temperature or n...

there are many reports for involvement of atp-sensitive potassium channels in pancreatic, cardiac and vascular smooth muscle cells. this study examined the effect of single doses of k+ channel openers diazoxide, minoxidil and k+ channel blockers chlorpropamide, glibenclamide on serum concentration of aldosterone in male rats. blood samples were obtained 60 minutes after drug treatment and serum...

objective(s):the aim of this study was to evaluate, for the first time, whether the effects of low-dose adropin administration is effective in rats with hyperlipidemia. materials and methods: twenty one wistar albino female rats were randomly divided into 3 groups and fed with high-fat diet for 4 weeks to establish the hyperlipidemia model. meanwhile, adropin was administrated intraperitonealy ...

conclusions hexagonal water has no significant effect(s) on total cholesterol, hdl, and ldl; however, more experiments are needed to clarify all aspects of hexagonal water consumption on diabetes. background diabetes is one of the most prevalent abnormalities in all over the world. nowadays, there are lots of attempts to reduce its disturbances and defects by changing life style to access some ...

background: designing the effective and early interventions can prevent progression of prediabetes to diabetes. few studies have shown the effect of flaxseed on glycemic control. this study aimed to assess the effect of flaxseed powder on insulin resistance (ir) indices and blood pressure in prediabetic individuals. materials and methods: in a randomized clinical trial, 99 prediabetic individua...

In patients with diabetes who intend to fast during Ramadan, self-monitoring of blood glucose (SMBG) is an important tool. During this month, a long established treatment regimen, including medications, physical activity and diet plan, is changed to achieve concordance with the rules of fasting. Without proper glucose monitoring, it is not possible to achieve good glycaemic control.

OBJECTIVE To look for technical simplification and economic efficiency in the treatment of pediatric diabetic ketoacidosis (DKA) with subcutaneous use of the fast-acting insulin analog (lispro) and compare its use with regular intravenous insulin treatment. RESEARCH DESIGN AND METHODS In this controlled clinical trial from June 2001 to June 2003, we randomized 60 episodes of DKA with a blood ...

OBJECTIVES This paper reviews available information on insulin regimens that may enable patients with type 1 diabetes mellitus to fast during the month of Ramadan with minimal complications. It also provides guidance for health care professionals in managing patients who wish to observe the fast. METHODS Relevant English-language articles were identified through searches of the MEDLINE, EMBAS...

The effect of different periods of fasting on oral glucose tolerance was investigated in 33 subjects. It was found that glucose tolerance deteriorated as the fasting period became shorter. This effect was seen almost exclusively in subjects over 40 years of age. Only the fasting blood sugar was affected by the duration of the pretest fast in younger subjects.