Syringomyelia is a progressive neurological disorder in which fluid-filled cyst known as syrinx forms within the spinal cord. The case of 20-year adult presented with lower limb stiffness and difficulty walking for last 3 years. For 1 year, he also developed upper limbs. Upon examination, had spastic gait no ataxia. There was muscle wasting both limbs, fasciculation. Tone increased reduced powe...

During neural development, the axons of sensory and motor neurons must extend over long distances—meters in some animals—to reach the most distant parts of the limbs. The axons of these neurons adhere tightly together to form spinal nerves that project over these distances to their peripheral targets. This process, called fasciculation, controls axon outgrowth and guidance. However, the underly...

We report the case of an unusual presentation of myasthenia gravis with tongue atrophy and fasciculation. Myasthenia gravis is an autoimmune condition associated with weakness and fatigability of voluntary muscles. In >50%, the initial symptoms and signs are related to extraocular muscle weakness, such as diplopia or ptosis [Tsung K, Seggev JS. An unusual cause of dysphagia. West J Med 1995; 16...

Background: It is becoming apparent that although inhibition of cholinesterase plays a key role in organophosphate (OP) toxicity, other factors are also important. One of the contributing factors for severity of OP poisoning is electrolyte imbalances such as hypokalemia. This study was aimed at evaluating the value of hypokalemia in association with plasma cholinesterase (PChE) levels in predic...

Growing axons use environmental cues to guide them to their targets. One class of cues is thought to be adhesion molecules on cells and in the extracellular matrix that axons interact with as they grow to their targets. In choosing between two possible pathways, the relative adhesiveness of the two substrates could be an important factor in controlling neurite growth. We conducted experiments i...