background: we aimed here to investigate the association between alleles and genotypes of apoe and age-related macular degeneration (amd) development. materials and methods: after ophthalmological examination, 120 patients with confirmed amd and 120 healthy controls were enrolled in the study. the polymorphic segment of apoe gene was pcr-amplified and sequenced to determine the frequency distri...

purpose: to evaluate the clinical features, and functional and anatomical outcomes of surgical intervention for pediatric rhegmatogenous retinal detachment (rrd). methods: in this retrospective case series, pediatric patients with rrd who had undergone surgical intervention were included. cases were categorized into five main etiological groups: congenital or developmental (48 eyes), traumatic ...

purpose : to offer a semi-automatic algorithm to determine the area of angiographic hyperfluorescence methods : the proposed algorithm included wavelet filter, histogram equalization and modified otsu thresholding. hyperfluorescent area of 30 angiographic images obtained from patients with leaking choroidal neovascularization (cnv) and diabetic retinopathy were evaluated and the results were co...

objective(s): predegeneration is a standard technique to obtain mitotically activated and enriched cultures of schwann cells (scs). this study, for the first time, evaluated the impact of various duration of predegeneration on cell yield and enrichment of scs from dog peripheral nerve. materials and methods: dog sural nerves were subjected to 5, 10, 15 day-long in vitro predegeneration. the tot...

The RNA-dependent RNA polymerase (1E Pol ) is involved in replication of grapevine fanleaf virus (GFLV, Nepovirus , Secoviridae and causes vein clearing symptoms Nicotiana benthamiana . Information on protein 1E interaction with other viral host proteins scarce. To study biology, three GFLV infectious clones, i.e. GHu (a symptomatic wild-type strain), GHu-1E K802G (an asymptomatic mutant) F13 w...

Background & Aim: Low back pain is broadly documented as one of the most widespread pathologies in the advanced domain. Although the reasons of low back pain are uncountable, it has been meaningfully related to intervertebral disc degeneration. Present therapies for Intervertebral Disc (IVD) degeneration such as physical therapy and spinal fusion reduce symptoms' severity, but do not treat the ...

Background: lumbar disc degeneration is a multifactorial degenerative disease which is affected by genetic inheritance and environmental factors. Type XI collagen is important for organization of the extracellular matrix and cartilage collagen construction. Rs1676486 is a SNP that causes the conversion of C-T, resulting in a change in the expression of the collagen 11 alpha chain. The T allele ...