Famotidine Form B P. P. Upadhyay, M. K. Mishra, U. Ramamurty, A. D. Bond University of Copenhagen, Indian Institute of Science, University of Cambridge Purpose Polymorphs are well known to have different mechanical properties. Nanoindentation enables mechanical properties to be tested on single crystals, which should provide the best opportunity to establish a correlation with single-crystal X-...

OBJECTIVE Famotidine given at a dose of 80 mg/day is effective in preventing NSAID-induced gastropathy. The aim of this proof of concept study was to compare twice a day (BID) vs 3-times a day (TID) administration of this total dose of famotidine on intragastric pH in healthy volunteers. RESEARCH DESIGN AND METHODS Two analyses were undertaken: (1) a 13 subject controlled cross-over 24-h intr...

We previously reported that ranitidine, an H(2) receptor antagonist, inhibited neutrophil activation in vitro and in vivo, contributing to reduce stress-induced gastric mucosal injury in rats. In this study, we examined whether ranitidine would reduce ischemia/reperfusion-induced liver injury, in which activated neutrophils are critically involved, in rats. We also examined the effect of famoti...

BACKGROUND Gastric antisecretory agents may inhibit the synthesis or secretion of gastric mucin during acid suppression, which would interfere with mucosal protection and limit the efficacy of the agents. METHODS Rats were dosed with famotidine, omeprazole, or buffer control for 4 weeks. Mucin synthesis, mucin histochemistry, mucin carbohydrate composition and prostaglandin E2 (PGE2) release ...

Urticaria is a common pediatric skin disorder. Histamine H1-receptor antagonists are effective in chronic as well as acute urticaria. When H1-anti-histamines are ineffective, add-on use of H2-receptor antagonists is thought to give better symptom relief. However, there are few reports on the therapeutic efficacy in pediatric patients. We retrospectively reviewed the medical records of pediatric...

Endoscopic mucosal resection (EMR) results in the formation of iatrogenic gastric ulcers and the optimal treatments for such ulcers are still unclear. We aimed to evaluate the efficacy of rebamipide in the management of EMR-induced ulcers by comparing it with an H(2) receptor antagonist. After EMR, patients were randomly assigned into either rebamipide or famotidine groups. All patients receive...

Background: Currently available radioprotectors are poorly tolerated in man and the general use of aminothiols is compromised by their side effects. This study was carried out to test and compare the radioprotective potential of cimetidine and famotidine against lethally gamma irradiated NMRI mice. Materials and Methods: Adult male NMRI mice in groups of 10 were exposed to various doses of gamm...

 ABSTRACTBackground: Radioprotective effects of famotidine, an antagonist of H2 receptor clinically used for peptic ulcer treatment, was previously shown on radiation-induced micronuclei and chromosomal aberration in human peripheral blood lymphocytes and mouse bone marrow cells. This study was conducted to investigate radioprotective property of famotidine against radiation induced apoptosis i...

Abstract: Objectives: The intention of present study is to formulate and optimize the famotidine mucoadhesive tablets y using Central Composite Design. Materials Methods: concentrations Cordia dichotoma fruit mucilage powder (X1) Polyvinyl pyrrolidone (X2) were demonstrated as independent variables. Whereas, dependent variables selected such an in vitro Mucoadhesion Time percentage Drug Release...