The blood supply of myomatous uteri collected upon autopsy was examined. The uterine vascular beds were perfused via afferent vessels with fixative followed by Mercox resin and corroded after polymerisation of the resin. The vascular casts thus obtained were examined using scanning electron microscopy. The vascular system of the uterine fibroids was also examined using immunohistochemical analy...

By utilizing a simple modification of previous immunological assays, we have demonstrated that most, if not all, hemophilic plasmas contain antigen reactive with human antibodies directed against Factor VIII procoagulant activity (VIIIc). Antibodies developing in a nonhemophiliac patient and in a hemophiliac patient gave similar results. The VIIIc antigen so identified was removed from hemophil...

Approximately 15% of individuals with hemophilia A develop antibodies (inhibitors) to therapeutically infused factor VIII that interfere with F.VIII coagulant activity. By using isoelectric focusing and immunospecific detection of anti-factor VIII antibodies, inhibitor plasma showed varied patterns of reactivity characteristic of a polyclonal response. Inhibitor plasma from patient Bt was obser...

The clinical, pathological, and ultrastructural features of two cases of peritoneal cystic mesothelioma occurring in men were studied. The results of immunohistochemical staining for CAM 5.2, epithelial membrane antigen, carcinoembryonic antigen, and Factor VIII related antigen are reported for the first time and compared with the staining results of two peritoneal cystic lymphangiomas. Althoug...

Vascular transformation of lymph node sinuses in retroperitoneal and parapancreatic lymph nodes found incidentally in an autopsy case of 57-year-old male with liver cirrhosis is reported. The lining cells of the capillary like structure in this lesion were considered to be endothelial cells showing coagulation factor-VIII related antigen immunoreactivity, Ulex europaeus agglutinin I lectin bind...

To understand why this quest was so prolonged, one needs to go back to the technologies of the 1970s and 1980s. Factor VIII is a cofactor for conversion of factorX to factorXa by activated factor IX and is the rarest of all the clotting factors in blood. Not surprisingly, it was the last but one of the classical blood coagulation factors to yield to the advance of molecular biology (in 1984, 2 ...

many investigations have proved relations between abo blood groups with some diseases and factor viii and von willebrand level in plasma. in this study we investigated a relation between abo blood groups and factor viii and ix inhibitors in 102 patients with haemophilia a and 48 patients with haemophilia b. the assay of inhibitor was done by bethesda method. there were no relation between abo b...

UNLABELLED INTRODUCTION The development of factor VIII inhibitors is a serious complication of replacement therapy in patients with congenital hemophilia A. Immune tolerance induction has been accepted as the only clinically proven treatment allowing antigen-specific tolerance to factor VIII. However, some of its issues, such as patient selection, timing, factor VIII dosing, use of immunosup...

Hereditary deficiency of the macromolecular Factor VIII complex results in classic von Willebrand disease in man and animals, a bleeder state characterized by loss of the multiple biologic activities associated with the Factor VIII complex, including the platelet-aggregating von Willebrand factor. The bleeding time is also long. Venom coagglutinin, a Bothrops factor that causes platelet aggrega...