To the Editor: Hippo et al. (1) have recently reported in an article published by Cancer Research that glypican-3 (GPC3) is a serologic marker of hepatocellular carcinoma (HCC). The results published by Hippo et al. basically confirm the findings reported previously by our laboratory (2) and by Nakatsura et al. (3). The fact that three independent laboratories using different anti-GPC3 antibodi...

A healthy kidney produces final urine that is practically devoid of proteins and other physiologically important solutes. Tremendous amounts of fluid are filtered every day through the glomerular filtration barrier which is the actual sieving site in the kidney. Failure of the filtering function leads to proteinuria, which is a feature common to nearly all kidney disease. In spite of this pivot...

To the Editor: Hippo et al. (1) have recently reported in an article published by Cancer Research that glypican-3 (GPC3) is a serologic marker of hepatocellular carcinoma (HCC). The results published by Hippo et al. basically confirm the findings reported previously by our laboratory (2) and by Nakatsura et al. (3). The fact that three independent laboratories using different anti-GPC3 antibodi...

Abstract T he financial crisis in 2007-2008 has turned into the most far-reaching international financial and economic crisis since the Great Depression. Indeed, the crisis-affected Asian countries experienced varying degrees of changes in the exchange rate and prices following an initial shock of sharp depreciation of their currencies in the second half of 1997. Moreover,...

We read with interest the Article by Maxime Taquet and colleagues1Taquet M Geddes JR Husain Luciano S Harrison PJ 6-month neurological psychiatric outcomes in 236 379 survivors of COVID-19 : a retrospective cohort study using electronic health records.Lancet Psychiatry. 2021; 8: 416-427Summary Full Text PDF PubMed Scopus (827) Google Scholar The Lancet Psychiatry that evaluated large population...

In this issue of Clinical Cancer Research, Hu et al. assess the role of phosphatidylinositol 3-kinase (PI3K) inhibition in vascular permeability, angiogenesis, and vascular remodeling in both tumor vessels and the peritoneal lining an athymic mouse model of intraperitoneal human ovarian carcinoma (1). Ovarian cancer is a vicious disease. Often, ovarian cancer presents unexpectedly at an advance...

In this issue of Cancer Research , two epidemiologic studies investigating the association between genetic variants on chromosome 8q24 and prostate cancer are published. The purpose of this editorial is to comment on the importance and implications of these findings and to explain the rationale of the journal for publishing not just one but two epidemiologic studies on 8q24 and prostate cancer....

There is little question that aspirin can decrease the risk of large bowel cancer. A large number of observational studies in humans, both case-control and cohort, consistently show a strong protective effect of aspirin (1). Importantly, three randomized controlled trials show that aspirin decreases the risk of new adenomas in humans (2-4). Because most colorectal cancers arise from adenomas, t...

•FRET sensors in Sla2 report the actin-generated forces required for endocytosis•At least 8 pN force is transmitted by Sla2-Ent1 membrane-actin protein linker•Large amount of needed initial membrane bending and early invagination•Lowering cell turgor or tension reduces over linker Mechanical are integral to many cellular processes, including clathrin-mediated endocytosis, a principal traffickin...