Abstract Ultraviolet B (UVB) light is a common environmental trigger that can induce flares in several autoimmune diseases, but the mechanisms mediate UVB-induced photosensitivity remain poorly understood. We used mice which express an autoimmune-driving isoform of Foxp3, called FoxP3 ΔE2mice, to develop model cutaneous photosensitivity. In steady-state, ΔE2mice have high serum titers IgE targe...

w hether the united kingdom (uk) should remain in the european :union: (eu) or not has been a fiercely debated issue both before and after the referendum in the uk on june 23, 2016. the main purpose of this paper is to evaluate the pros and cons of the uk leaving the eu. it is concluded that if the uk leaves the eu, the resulting economic shock would risk adverse effects on macroeconomic variab...

1 Department of Mathematics Education, Wonkwang University, Iksan 570-749, Republic of Korea 2 Mathematics Department, College of Science, Suez Canal University, Ismailia 41522, Egypt 3 Department of Mathematics and Statistics, College of Science, Sultan Qaboos University, P.O. Box 36, Muscat, Alkhod 123, Oman 4 Vedant College of Engineering and Technology, Village-Tulsi, Post-Jakhmund, Bundi, ...

Abstract In normal wound healing, macrophages regulate early and late inflammation, allowing for resolution of tissue injury subsequent healing. During repair, undergo transition to myofibroblasts, which promote While this critical is impaired in diabetic wounds, the underlying mechanisms responsible are unknown. Our group others have identified that epigenetic regulation controls their phenoty...

Abstract T follicular helper (T FH) cells represent a distinct lineage of CD4 that engage with cognate B cells, facilitating the production high affinity vaccine- and pathogen-specific antibodies. In humans, FHcells can be detected in several tissues throughout body, each representing unique cellular environment complete signaling molecules. Despite FHcell importance to human health, it remains...