Electron-doped BaTiO3 is a less studied n-type metal oxide thermoelectric material. In this work, the electrical conductivity of samples has been improved by introducing La to yield an Ba1–xLaxTiO3 semiconducting Density functional theory calculations show that optimal electron-doping occurs at x = 0.2, and also confirmed experimentally. To improve properties further, nanostructured cuboidal po...

Hematite (α-Fe2O3) thin films with various nanostructures were synthesized through self-assembly between iron oxide hydroxide particles, generated by hydrolysis and condensation of Fe(NO3)3 · 6H2O, and a Pluronic triblock copolymer (F127, (EO)106(PO)70(EO)106, EO = ethylene oxide, PO = propylene oxide), followed by calcination. The self-assembly structure can be tuned by introducing water in a ...

This work evaluated the potential of Pluronics (varieties F127 and P123) in combination with solubilizing agents to be used as syringeable in situ gelling depots of intratumoral β-lapachone (βLAP). Pluronic dispersions prepared at various concentrations in the absence and the presence of ethanol and randomly methylated β-cyclodextrin (RMβCD) were characterized regarding their rheological proper...

Antisense oligonucleotide-mediated alternative splicing has great potential for treatment of Duchenne muscular dystrophy (DMD) caused by mutations within nonessential regions of the dystrophin gene. We have recently shown in the dystrophic mdx mouse that exon 23, bearing a nonsense mutation, can be skipped after intramuscular injection of a specific 2'-O-methyl phosphorothioate antisense oligor...

The development of effective strategies for local administration chemotherapeutic drugs, thus minimizing the adverse side effects to patients, is one key challenges in biomedicine and cancer research. This work reports formulation characterization PluronicF127 microemulsions enhance bioavailability Cisplatin (Cis). size Cis microemulsion was about 12.0 nm, as assessed by dynamic light scatterin...

Novel composites of highly ordered and stable biphenyl-bridged periodic mesoporous organosilica (PMO) materials confined within the pores of anodic alumina membranes (AAM) were successfully synthesized by evaporation-induced self-assembly (EISA). 4,40-Bis(triethoxysilyl)biphenyl (BTEBP) was used as a precursor in combination with the ionic surfactant cetyltrimethylammonium bromide (CTAB) or tri...

The surface of nanoparticles is often functionalised with polymeric surfactants, in order to increase systemic circulation time. This has been investigated mainly for intravenously administered nanoparticles. This study aims to elucidate the effect of surface coating with various concentrations of polymeric surfactants (PEG and Pluronics F127) on the in vitro protein binding as well as the tiss...

This work studied artemether (ARTM) solid dispersion (SD) formulation using mixture of polymer excipient Soluplus, PEG 400, Lutrol F127, and Lutrol F68 melts at temperatures lower than the melting point of ARTM using a laboratory-size, single-screw rotating batch extruder. The effects of three surfactants PEG 400, Lutrol F127, and Lutrol F68 and parameters like mixing temperature, screw rotatin...

BCS class III drugs suffer from a drawback of low permeability even though they have high aqueous solubility. The objective of current work was to screen the suitability of glyceryl monooleate (GMO)/Pluronic F127 cubic phase liquid crystals precursors for permeation enhancement and in turn the bioavailability of tenofovir disoproxil fumarate (TDF), a BCS class III drug. Spray-drying method was ...