objective(s):involvement of tyrosinase in the synthesis of melanin and cell signaling pathway has made it an attractive target in the search for therapeutic inhibitors for treatment of different skin hyperpigmentation disorders and melanoma cancers. materials and methods: in the present study, we conducted a comprehensive kinetic analysis to understand the mechanisms of inhibition imposed by 2-...

the effect of natural killer (nk) cells and lymphokine activated killer ( lak) cells was studied on a group of human melanoma cell lines. peripheral blood from healthy volunteers was utilized as a fresh source of natural killer cells and rhi l-2 for producing lak cells. the cytotoxicity of effector cells was quantified using a 4 hour si determining the density of antigen expression on tumor cel...

conclusions cmm in yazd is a low-incidence skin tumor that shows a relatively fixed incidence between 1988 and 2008, higher incidences of cmm were found in sun-exposed areas (especially head and neck areas), with more incidence in men. skin cancers and cmm incidence in iran is lower than western countries, most probably due to geographical zone, genetic factors, skin type, society-related custo...

background: nowadays, magnetic nanoparticles (mnps) have received much attention because of their enormous potentials in many fields such as magnetic fluid hyperthermia (mfh). the goal of hyperthermia is to increase the temperature of malignant cells to destroy them without any lethal effect on normal tissues. to investigate the effectiveness of cancer therapy by magnetic fluid hyperthermia, fe...

we report a young male with an initial excisional biopsy report of melanoma of the lower back, referred to our hospital for complete excision and sentinel lymph node (sln) biopsy.  four peritumoral intradermal tc-99m phytate injection was performed and slns were detected in both axillary and right inguinal regions. on the biopsy only the right axillary sln was metastatic leading to right axilla...

purpose : to assess the results of brachytherapy in patients with recurrent or incomplete excised conjunctival squamous cell carcinoma (scc) and malignant melanoma. methods : three patients underwent brachytherapy of one eye and one patient underwent brachytherapy of both eyes with ruthenium-106 (ru-106) plaques, all of them had a history of incomplete resection or recurrence of the tumor after...

Two new potential magnetic resonance imaging contrast agents, Gd-hematoporphyrin (Gd-H) and Gd-tetra-carboranylmethoxyphenyl-porphyrin (Gd TCP), were synthesized and applied to nude mice with human melanoma (MM 138) xenografts. These agents showed a high relaxivity because of their greater potential to coordinate water molecules. The reduction of T1 relaxation times of 16 and 21% was observed i...

The effect of natural killer (NK) cells and lymphokine activated killer ( LAK) cells was studied on a group of human melanoma cell lines. Peripheral blood from healthy volunteers was utilized as a fresh source of natural killer cells and rhI L-2 for producing LAK cells. The cytotoxicity of effector cells was quantified using a 4 hour SI determining the density of antigen expression on tumor...

Melanoma has been reported a contemporary malignant cancer. Here, anti-cancer effects of sea cucumber extract (SCE) have been examined on melanoma cells and compared with dacarbazine. MTT assay and morphological analysis were performed to evaluate cytotoxic effects of methanolic SCE Also, several methods were exerted to detect cell dying by SCE and dacarbazine. The MTT assay showed that B16F10 ...

Introduction In order to treat uveal Melanoma , first, radioactive seeds are laid on a silicone- made substance which is called Silastic after that they are inserted in the plaque, and finally, this plaque containing silicone-made substance is stitched to the sclera surface. The dose gradient within the tumor and healthy tissues can be varied due to changing the Silastic thickness between scler...