The effect of genotype, sex and hatch on carcass traits and physical characteristics of eggs was investigated in the Japanese quail. Two strains of Japanese quails including the White (P1) and Wild (P2) genotypes were chosen as the parental generation and crossed reciprocally (10 singlepair mating) to create the F1 progeny. The F1 birds (27 males and 81 females) were mated randomly to produce t...

Epidemiological studies have shown an association between low birthweight and adult disease development with transmission to subsequent generations. The aim of the present study was to examine the effect of intrauterine growth restriction in rats, induced by uteroplacental insufficiency, on cardiac structure, number, size, nuclearity, and adult blood pressure in first (F1) and second (F2) gener...

Generating coherent discourse is an important aspect in natural language generation. Our aim is to learn factors that constitute coherent discourse from data, with a focus on how to realize predicate-argument structures in a model that exceeds the sentence level. We present an important subtask for this overall goal, in which we align predicates across comparable texts, admitting partial argume...

F1-ATPase (F1) is a rotary motor protein that can efficiently convert chemical energy to mechanical work of rotation via fine coordination of its conformational motions and reaction sequences. Compared with reactant binding and product release, the ATP hydrolysis has relatively little contributions to the torque and chemical energy generation. To scrutinize possible roles of ATP hydrolysis, we ...

Recent studies show that emotional and environmental stimuli promote epigenetic inheritance and influence behavioral development in the subsequent generations. Caloric mal- and under-nutrition has been shown to cause metabolic disturbances in the subsequent generation, but the incentive properties of paternal binge-like eating in offspring is still unknown. Here we show that paternal sucrose se...

We investigated the effects of statin treatment on platelet-derived microparticles (PMPs) and thrombin generation in atherothrombotic disease. Nineteen patients with peripheral arterial occlusive disease were randomised to eight weeks of treatment with atorvastatin or placebo in a cross-over fashion. Expression of GPIIIa (CD61), P-selectin (CD62P), tissue factor (TF, CD142) and phosphatidylseri...

BACKGROUND It has been suggested by clinical, epidemiological, and experimental in vitro studies that homocysteine potentiates thrombin generation. This prothrombotic effect however has not previously been demonstrated in patients presenting with acute coronary syndromes (ACS). METHODS AND RESULTS Patients with ACS (n =117) presenting with confirmed acute myocardial infarction (MI) (n =57) or...

These two subspecies of house mouse were found to differ in their social behaviour, the former being less aggressive than the latter. The paternal effect on aggression (observed repeatedly in laboratory mice) was not found. However, F2 generation mice were less aggressive than those from the F1 generation, and the maternal effect was also significant in a homogenous test set.

OBJECTIVE Parental obesity can induce metabolic phenotypes in offspring independent of the inherited DNA sequence. Here we asked whether such non-genetic acquired metabolic traits can be passed on to a second generation that has never been exposed to obesity, even as germ cells. METHODS We examined the F1, F2, and F3 a/a offspring derived from F0 matings of obese prediabetic A (vy) /a sires a...

Gestational diabetes mellitus (GDM) has been shown to be associated with high risk of diabetes in offspring. However, the mechanisms involved and the possibilities of transgenerational transmission are still unclear. We intercrossed male and female adult control and first-generation offspring of GDM (F1-GDM) mice to obtain the second-generation (F2) offspring in four groups: C♂-C♀, C♂-GDM♀, GDM...