OBJECTIVES The present study was designed to evaluate the usefulness of deep dry needling in the treatment of temporomandibular myofascial pain. STUDY DESIGN We selected 36 patients with myofascial pain located in the external pterygoid muscle (30 women/6 men, mean age=27 years with SD±6.5). We studied differences in pain with a visual analog scale and range of mandibular movements before and...

Polymer–drug conjugates are an important polymeric therapeutic (PT) platform with drug molecules being attached by cleavable linkages to the pendant functional groups of linear, branched, brushed polymers that are typically synthesized prior to drug conjugation. The synthesis and conjugation processes developed to date, however, may not provide precise control over the composition and the struc...

BACKGROUND Although percutaneous trigger digit release is common, controversy exists regarding its safety. The purpose of this study was to evaluate the feasibility and safety of the neurovascular displacement by local hydraulic dilatation (LHD) during percutaneous trigger digit release. MATERIAL AND METHODS Ten cadaver hands with 50 digits were dissected in this anatomical study. The distance ...

INTRODUCTION Congenital trigger thumb is an uncommon anomaly of children. Its management is controversial, ranging from observation to extensive surgical release. We report a case of delayed presentation of bilateral trigger thumb along with a brief review of past literature. CASE REPORT A six year old girl presented with fixed flexion deformity of interphalangeal joints of both thumbs and No...

mycophenolic acid (mpa) is the active metabolite of mycophenolate mofetil. this study designed to investigate the mechanism of cytotoxicity of mpa on the genetically engineered pc12 tet off (pto) neuronal cells with p53 gene. alamar blue (ab) reduction showed concentration-dependent cytotoxicity of mpa on pto cells with ic50 value of 32.32 ± 4.61 mm. the reactive oxygen species (ros) generation...

Triggered drug delivery devices use external stimulus to trigger the release of drugs from device. By controlling exposure stimuli, it would allow for control over timing, duration and amount being released device, improving efficacy. 3D printing uses on-demand deposition crosslinking materials fabricate a product, increasing customisability design internal structure. using triggered devices, c...

Here we summarize the evidence from two "giant" presynaptic terminals-the squid giant synapse and the mammalian calyx of Held-supporting the involvement of nanodomain calcium signals in triggering of neurotransmitter release. At the squid synapse, there are three main lines of experimental evidence for nanodomain signaling. First, changing the size of the unitary calcium channel current by alte...