Controlling COVID-19 requires therapy and continued vaccination. Long-acting therapeutics offer options for test-and-cure strategies overcome poor adherence. Extended in vivo niclosamide exposure is demonstrated here as such a candidate.

In this prospective study we examined the effect of prolonging cultures of peritoneal dialysis fluid to 21 days. The extended culture period did not lead to any new or clinically important findings, although late culture findings were obtained in a small number of cases. Prolonged culture of the effluent does not appear to be necessary, although it can lead to extended duration of antibiotic th...

OVERVIEW OF THE ISSUE The appropriate management of superficial and deep pyoderma requires the use of both topical and systemic therapy. Topical therapy is often used as an adjunctive to systemic antibiotics because it will speed the healing process, aid in the elimination of bacterial byproducts and generally make the patient feel better. Topical therapy can also be used as a preventative ther...

BACKGROUND Stabilization of rapid-cycling bipolar disorder is extremely difficult. METHODS A refractory bipolar I rapid-cycling patient on valproate was treated with long "nights" (extended sleep in darkness) and daytime light therapy. RESULTS Rapid cycling immediately stopped on initiation of a 10 hour dark/rest period. This was extended to 14 hours (plus a self-selected 1 hour midday nap)...

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