The TREX complex (TREX) plays key roles in nuclear export of mRNAs. However, little is known about its transcriptome-wide binding targets. We used individual cross-linking and immunoprecipitation (iCLIP) to identify the binding sites of ALYREF, an mRNA export adaptor in TREX, in human cells. Consistent with previous in vitro studies, ALYREF binds to a region near the 5' end of the mRNA in a CBP...

Human immunodeficiency virus type 1 (HIV-1) gene expression in astrocytes is restricted, resulting in a brief and limited synthesis of HIV-1 viral structural proteins. Impaired Rev function has been documented in these cells. However, the molecular mechanisms underlying the impaired Rev function are not fully understood. Using the astroglial cell line U87.MG as a model, we report here that HIV-...

In the next decade, India is likely to witness changes in its cotton and textile sectors as many of the constraints on production, marketing, and trade of cotton and textile products are set to be eliminated. Some of the internal constraints include export constraints on yarn, government fixing of cotton ginning and pressing fees, and subsidization of raw cotton production. Similarly, one of th...

The majority of the literature currently in existence on trade and pollution has concentrated analysis both factors’ combined effects, only a few studies have used heterogeneous environmental regulation as starting point to investigate underlying mechanisms impact export at indirect level. We construct mediating moderating effect model using panel data from 30 provinces China 2002 2019 mechanis...

internationalization is a matter of committed decision-making that starts with export marketing, in which an organization tries to diagnose and use opportunities in target markets based on realistic evaluation of internal strengths and weaknesses with analysis of macro and microenvironments in order to gain presence in other countries. a developed model for export and international marketing of...