Plant extracts are the most attractive sources of newer drugs and have been shown to produce promising results for the treatment of gastric ulcers. Karanjin, a furano-flavonoid has been evaluated for anti-ulcerogenic property by employing adult male albino rats. Karanjin (>95% pure) was administered to these rats in two different concentrations, that is, 10 and 20 mg kg(-1) b.w. Ulcers were ind...

PURPOSE To report a specific line of research developed at the University of São Paulo/Brazil on fibrin glue used for sealing corneal perforations and the perspectives of use on non-perforated corneal ulcers and photorefractive keratectomy-operated corneas. METHODS To describe fibrin glue manufacture, development of a device to test the glued perforated corneal area resistance, subsequent exp...

BACKGROUND Standard compression therapy for venous ulcers of the legs does not promote healing. Although autografting accelerates tissue repair, it is difficult to use in patients with concomitant diseases or when multiple grafts are required. The amniotic membrane has been used as a covering material and promotes epithelialization, making it a good potential treatment option when autografts ar...

Treatment with growth factors is an effective method to promote wound healing. Several growth factors have been used in wound treatment, including basic fibroblast growth factor (bFGF) discovered in the 1970s, platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and bone morphogenetic protein (BMP). In 2001, Kaken Pharmaceutical Co., Ltd. launched Fiblast Spray in Japan. This p...

An ideal operation for a benign disease, such as duodenal ulcer, must be effective, relatively free of serious postoperative complications and standardized for effective performance. Highly selective vagotomy, an operation known to have few side effects, has not been adopted by many surgeons because of the concerns about postoperative recurrent ulcers, as well as by concerns about the technical...

pressure ulcers result from immobility and continuous pressure on an area of body. besides imposing further restriction of movements and thus creating a vicious circle in the healing process, these ulcers are of significant importance in decreasing the life quality and increasing the costs of treatment in these patients. in this study we compared the outcome of treatment of pressure ulcers with...

Recent work has shown that the new antiviral acyclovir (acycloguanasine) is a highly effective antiviral drug against the herpes simplex virus."2 It acts mainly on virally infected cells by blocking viral particle formation before the particles pass through the nuclear membrane3 by means of inhibiting viral DNA polymerase after being converted by virally specific thymidine kinase.4 In tissue cu...

Pressure ulcers are costly and life-threatening complications for people with spinal cord injury (SCI). People with SCI also exhibit differential blood flow properties in non-ulcerated skin. We hypothesized that a computer simulation of the pressure ulcer formation process, informed by data regarding skin blood flow and reactive hyperemia in response to pressure, could provide insights into the...