The present study was designed to examine the activity of the sodium-independent chloride-bicarbonate anion exchanger and the sodium-proton exchanger in erythrocytes of 30 normotensive and 35 hypertensive subjects and its relation to the previously reported decrease in erythrocyte pH. Erythrocyte cytosolic pH was measured by the pH-sensitive fluorescent probe 2'-7'-bis(2-carboxyethyl)- 5(6)-car...

The brush border membrane of the proximal tubule contains two efflux pathways for organic cations from the cell to the tubular fluid: a P-glycoprotein and an organic cation/H+ exchanger. There is evidence that they transport many of the same substrates. Their structural relatedness is unknown and is the subject of this report. The experimental approach was to identify the exchanger with photoaf...

pinch technology is one of the best methods for designing a multi stream heat exchanger(mshe) through a network; current pinch-based methods, however, lead to a larger and more complicateddesign problems. the major drawback of the current methods is they result in designs having more individual mshe sections than essential, correspond to the enthalpy intervals on temperature vs. enthalpy diagra...

This two-part study explores the development and thermal performance of a coiled-tube heat exchanger for hydrogen fuel cell storage systems utilizing High-Pressure Metal Hydride (HPMH). The primary purpose of this heat exchanger is to tackle the large amounts of heat released from the exothermic hydriding reaction that occurs when the hydrogen is charged into the storage vessel and is absorbed ...

We previously cloned an isoform Na+/H+ exchanger (NHE3), which was expressed only in intestine, kidney, and stomach. We show here the functional characteristics of NHE3 as a Na+/H+ exchanger by stably transfecting NHE3 cDNA into PS120 cells, a fibroblast cell line that lacks endogenous Na+/H+ exchangers. NHE3 was 39- and 160-fold more resistant to inhibition by amiloride and ethylisopropyl amil...

The activity of the cardiac Na+/Ca2+ exchanger is stimulated allosterically by Ca2+, but estimates of the half-maximal activating concentration have varied over a wide range. In Chinese hamster ovary cells expressing the cardiac Na+/Ca2+ exchanger, the time course of exchange-mediated Ca2+ influx showed a pronounced lag period followed by an acceleration of Ca2+ uptake. Lag periods were absent ...

The regulation of cytosolic Ca2+ concentration during excitation-contraction coupling is altered in the failing human heart. Previous studies have focused on disturbances in Ca2+ release and reuptake from the sarcoplasmic reticulum (SR), whereas functional studies of the cardiac Na(+)-Ca2+ exchanger, another important determinant of myocyte homeostasis, are lacking for the failing human heart. ...

C3MR, MFC, and DMR processes in an integrated LNG-NGL-NRU structure are investigated using the conventional and advanced exergy and exergoeconomic analyses. The results of advanced exergy analysis reveal that in most of the equipment, the highest amount of irreversibility is occurred because of endogenous exergy destruction. In C3MR process, compressor C5 with 9730 kW; in MFC process, compresso...

In this paper the thermal behavior of the shell-side flow of a shell-and-tufe heat exchanger has been studied using theoretical and experimental methods. The experimental method Provided the effect of the major parameters of the shell-side flow on thermal energy exchange. In the numerical method, besides the effect of the major paramerers, the effect of different geometric parameters and Re on ...