Omega-3 rich fish oils are extremely labile, thus requiring control of oxidation and off flavor development. A recently proposed emulsification method, layer-by-layer (LbL) deposition, was found to be a plausible method to enhance the characteristics of bioactive ingredients, especially lipids. The present work was designed to test the possibility of enhancing the uptake and utilization of omeg...

assist the surgeon when asked to do so; that is to say, suppose in a case of this kind that the sac is difficult to find, the patient is directed to cough, down comes the gut and the sac is easily traced. As regards pain, there certainly cannot be any, nor ?does the patient exhibit the least sign of uneasiness. Now to English operators it may appear somewhat disconcerting to have a patient, so ...

WILSON, T. HASTINGS AND BERNARD R. LANDAU. S’$ec$!city of sugar transport by intestine of the hamster. Am. J. Physiol. Ig8( I) : 99-102. 1g6o.-The specificity of the sugar transport system of the hamster small intestine was tested with 20 sugars and sugar derivatives not previously tested in this system. The absorption of sugars across the intestinal wall against a concentration gradient was te...

WILSON, T. HASTINGS AND BERNARD R. LANDAU. S’$ec$!city of sugar transport by intestine of the hamster. Am. J. Physiol. Ig8( I) : 99-102. 1g6o.-The specificity of the sugar transport system of the hamster small intestine was tested with 20 sugars and sugar derivatives not previously tested in this system. The absorption of sugars across the intestinal wall against a concentration gradient was te...

PURPOSE To study single dose pharmacokinetics and bioavailability of the synthetic glucosamine analogue, N-butyryl glucosamine (GLcNBu) after different routes of administration, and also the effect of food following oral doses of GLcNBu in the rat, and stability and absorption of GLcNBu across the rat everted intestine. METHOD GLcNBu was administered intravenously (i.v.), intraperitoneally (i...

PURPOSE This present study investigated the absorption kinetics of echinacoside (ECH) in situ and in vitro and its oral bioavailability in rats. Additional aim was to find an agent(s) to promote ECH absorption and oral bioavailability among two efflux proteins and three absorption promoters. METHODS ECH absorption behaviors were investigated by everted gut sac model in vitro and single-pass i...

Background Andrographolide (AG), a compound with low water solubility, possesses various pharmacological activities, particularly anti-inflammatory activity. However, its low oral bioavailability is a major obstacle to its potential use. This study developed and optimized an AG-loaded nanoemulsion (AG-NE) formulation to improve AG oral bioavailability and its protective effects against inflamma...

Nerium indicum is an India-Pakistan-originated shrub belonging to the oleander family. The ingestion of leaves of N. indicum before a meal is known to effect the lowering of postprandial glucose levels in Type II diabetic patients and this plant is now used as a folk remedy for Type II diabetes in some regions of Pakistan. In the present study, the hot-water extract of N. indicum leaves was fou...

Previous structure-activity studies of the active ileal bile salt transport system have demonstrated that a single negative charge on the side chain is essential for active transport. Furthermore, mutual inhibition studies between different pairs of bile salt substrates indicated that dihydroxy bile salts had a greater apparent affinity for the transport system than the trihydroxylated compound...