A time dependent pulsed release system consisting of an effervescent core surrounded by consecutive layers of swelling and rupturable polymers was prepared and evaluated. The cores containing salbutamol sulphate as bioactive agent were prepared by direct compression method using different ratios of microcrystalline cellulose and effervescent agent and then coated sequentially with an inner swel...

Verapamil hydrochloride is an antihypertensive agent which undergoes extensive first pass metabolism making it a possible candidate for buccal delivery. Verapamil mucoadhesive buccal patches were prepared using hydroxypropyl methylcellulose, Eudragit RL 100, sodium carboxymethyl cellulose and carbopol. The physicochemical interactions between verapamil and physical mixture were investigated by ...

Objective(s): Ketotifen fumarate (KF) is a selective and noncompetitive histamine antagonist (H1-receptor) that is used topically in the treatment of allergic conditions of rhinitis and conjunctivitis. The aim of this study was to formulate and improve an ophthalmic delivery system of KF.Ocular nanoparticles were prepared with the objective of reducing the frequency of administration and obtain...

The investigation is to study the effect of polymers on compressibility and release of Metoprolol Tartarate from tablet through direct compression. Tablets were prepared by direct compression by mixing with commonly used polymers, Eudragit RL-100, Chitosan, Ethyl cellulose, Hydroxyethyl cellulose and hydroxypropylmethyl cellulose K-100 in 1:1 ratio. The compressibility parameters were estimated...

Transdermal therapeutic systems (TTS) containing captopril were developed by using synthetic and pH independent polymers, Eudragit RL 100 and RS 100. The formulations were characterized in terms of their appearance, thickness, captopril content, in vitro release rate and diffusion profiles. In vitro release studies demonstrated controlled release for each formulation developed. In viro and ex v...

For improving bioavailability in controlled release fashion and to circumvent the hepatic first pass effect of glipizide mucoadhesive buccal films of glipizide were prepared by solvent casting technique. Buccal films were prepared using hydroxy propylmethylcellulose, sodium carboxymethylcellulose, carbopol934P and Eudragit RL-100. Films were evaluated for their weight, thickness, surface pH, sw...

The aim of the present study was to prepare unidirectional buccal films of buspirone hydrochloride by solvent casting technique. Hydroxypropylmethylcellulose (HPMC K15M) and Eudragit RL-100 were used as polymers in different proportion. Polyethylene glycol 400 and sodium lauryl sulphate were used as plasticizer and permeation enhancer, respectively, in different concentration. In the formulatio...

INTRODUCTION Extensively used polymers in biomedical applications are naturally occurring or synthetic compounds consisting of large molecules obtained from linking of simple monomers. Potential biomedical applications of these polymers include carrier based drug delivery systems, tissue engineering scaffold and cell culture supports [1]. Polymer based drug delivery system can control the rate ...

The aim of this study was to develop the polymer coated diclofenac tablet containing superdisintegrant for colonic drug delivery and compare the in vivo performance of two polymers for site specificity. Eudragit FS 3D and Eudragit S100 were used as pH sensitive polymers. Tablets were prepared to give fast release at specific site with the help of sodium starch glycolate as superdisintegrant. Ta...