Netherton’s syndrome Cyclosporine Dr. A.A. Ramelet, 2, place Benjamin-Constant, CH-1003 Lausanne (Switzerland), Tel. 021 312 60 60, Fax 021 320 40 90 In 1958, Netherton [IJ reported a unique case of trichorrhexis nodosa ‘bamboo hairs’. Netherton’s syndrome (NS) consists of the triad of ichthyosiform dermatosis, multiple defects of the hair shaft (trichorrhexis invaginata) and an atopic diathesi...

Sir, (WellferonB , Glaxo-Wellcome), natural leukocyte (CilferonB , Janssen-Cilag) and raIFN (Intron-AB , Schering-Plough), 3 It is well known that prolonged administration of recombinant alpha interferon (raIFN) in several viral and malignant disMU intramuscularly, daily or on alternate days depending on the clinical outcome, evaluated as in our former paper (4). eases can be followed by loss o...

A ny discussion of psoriasis treatments must include the setting in which such treatments are administered. Traditionally these comprise in patient hospitalization, ambulatory day-care-center treatment such as with the Ingram or Goeckerman regimens, outpatient phototherapy with ultraviolet B (UVB) or with psoralen and ultraviolet A (PUVA), and home care under the supervision of a physician in a...

Case report A 36 year old white man had a 20 year history of severe intractable psoriasis that required numerous admissions to hospital for inpatient treatment. He had long periods of erythrodermic psoriasis and underwent many forms of treatment, including psoralens and ultraviolet A, methotrexate, razoxane, and etretinate, in an attempt to control his psoriasis. In November 1984 he developed a...

Retinoic acid, which induces the differentiation of HL 60 cells to granulocytes, produces a cell alkalinization from pHi = 7.03 to pHi = 7.37. The half-maximum effect of retinoic acid is observed at 10 nM. The effect of retinoic acid on the pHi develops slowly, and it precedes the differentiation of the cells. A cell alkalinization is also observed after differentiation of the cells by dimethyl...

Several studies have suggested that murine and human keratinocytes respond differently to phorbol 12-myristate 13-acetate (PMA). Using an in vitro assay, we found that in contrast to its effect on murine skin, PMA did not induce ornithine decarboxylase (ODC) activity in human skin biopsies. To explore the signalling induced by PMA and to determine whether an in vitro culture system could be use...

BACKGROUND CCNU and other treatment protocols are commonly offered to owners for the treatment of dogs diagnosed with cutaneous (epitheliotropic) T-cell lymphoma (CTCL). Chemotherapy protocols provide variable benefits; they have different side-effects, and they typically require monitoring to detect drug toxicity at a non-negligible cost to the owner. At this time, even though CCNU is most oft...