In this work, the synthesis and solution self-assembly of partially fluorinated cationic polyelectrolytes based on post-polymerization-modified poly(2-(dimethylamino) ethyl methacrylate), incorporating hydrophobic groups along polymer chain, is reported. The post-polymerization modification aims to establish amphiphilic characteristics strong polyelectrolyte properties polymer. Therefore, self-...

Therapeutics such as proteins, DNA, or siRNA, can only exert their function in the cell cytosol or nucleus. However, most of them are cell membrane impermeable molecules that can only be taken up by cells via endocytosis or phagocytosis. Such drug molecules are thus confined in endolysosomes, where reduced pH and degradative enzymes may destroy them without therapeutic gain. Efficient escape of...

We investigated the structural features of micelles formed by the self-association of the pentablock copolymer poly[ N,N -(diethyl amino)ethyl methacrylate]-block-poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethyleneoxide)-block-poly[ N,N -(diethylamino)ethyl methacrylate] (PDEAEM-PEO-PPO-PEO-PDEAEM) in aqueous solutions by using small-angle neutron scattering SANS. The pentabloc...

Lansoprazole fast-disintegrating tablet (LFDT) is a new patient-friendly formulation of lansoprazole. Since lansoprazole is an antiulcer agent and is unstable under acidic conditions, we have developed LFDT as an orally disintegrating tablet containing enteric-coated microgranules. The effect of compression on dissolution behavior was investigated, as compression affected cleavage and crushing ...

Phase transition behavior of unimolecular dendritic three-layer nanostructures with dual thermoresponsive coronas is studied. Successive reversible addition-fragmentation transfer (RAFT) polymerizations of N-isopropylacrylamide (NIPAM) and 2-(dimethylamino)ethyl methacrylate (DMA) were conducted using fractionated fourth-generation hyperbranched polyester (Bolton H40) based macroRAFT agent. At ...

Weak polyelectrolyte brushes exhibit pH-responsive swelling behaviour, tuneable surface 10 In this paper, we demonstrate the growth of two weak polybase brushes by surface-initiated atom transfer radical polymerisation (SI-ATRP) using electrostatically adsorbed polyelectrolyte macro-initiators. Poly[2-(diethylamino)ethyl methacrylate] (PDEA) and poly[2-(diisopropylamino)ethyl methacrylate] (PDP...

This study reports a novel nanoparticle system with simple and modular one-step assembly, which can respond intelligently to biologically relevant variations in pH. Importantly, these particles also show the ability to induce escape from the endosomal/lysosomal compartments of the cell, which is integral to the design of efficient polymeric delivery systems. The nanoparticles were formed by the...

As inspired by the Dot blot analysis, a well known technique in molecular biology and genetics for detecting biomolecules, a new paper-based platform for colorimetric detection of specific DNA sequences employing peptide nucleic acid (PNA) as a probe has been developed. In this particular study, a pyrrolidinyl PNA bearing a conformationally rigid d-prolyl-2-aminocyclopentanecarboxylic acid back...