The ATP-dependent potassium (KATP) channel in the pancreatic beta-cell is a complex of two proteins, the pore-forming Kir6.2 and the sulfonylurea receptor type 1 (SUR1). Both subunits are required for functional KATP channels because expression of Kir6.2 alone does not result in measurable currents. However, truncation of the last 26 or 36 amino acids of the C terminus of Kir6.2 enables functio...

Esters of a hitherto undescribed xanthophyll, now called eschscholtzxanthin, are the principal constituents of the pigment mixture found in the brilliant, golden yellow petals of the California poppy, Eschscholtxia calijornica (l-3) .l Free eschscholtzxanthin, obtained by saponifktion of the esters, has the empirical formula G0H51*~02. The eschscholtzxanthin molecule contains twelve double bond...

The effect of esterification at the 2'-position of desosamine on the antibacterial activity of erythromycin was investigated by determining the bacteriostatic and bactericidal activities of erythromycin and a number of its 2'-esters on S. aureus and relating these activities to the hydrolysis rates of the esters. These studies, together with comparison of the inhibition of protein synthesis in ...

Stimulation of the phosphatidylinositol cycle by neurotransmitters generates diacylglycerol, an activator of protein kinase C, which may regulate some forms of neurotransmission. Phorbol esters, potent inflammatory and tumor-promoting compounds, also activate protein kinase C. We demonstrate potent and selective effects of phorbol esters on smooth muscle, indicating a role for protein kinase C ...

Esters of tetramethylcyclopropanecarboxylic acid (I) with (•})-allethrolonel1), (•}) -pyrethrolone2) and some others3) have activity comparable to that of corresponding esters of natural (+)-transchrysanthemic acid against some insect species. However, these esters show differences in toxicity to mammals which are probably resulted from differences in rates or pathways of metabolism. Therefore,...

-A tumour initiating dose of ethyl carbamate was administered to mice by subcutaneous injection together with a dose of one of the homologous esters or an ethyl N-alkyl derivative. The homologues used were the methyl, n-propyl and n-butyl esters, and the derivatives were the N-methyl, N-ethyl and N-n-propyl ethyl esters. The mice were then given promoting treatment with croton oil for 28 weeks....

A study was conveyed to produce estolide ester using ricinoleic acid as the backbone. The ricinoleic acid reacted with saturated fatty acid from C8-C18. These reactions were conducted under vacuum at 60°C for 24 h without solvent. The reaction used acid catalyst, sulphuric acid. The new saturate ricinoleic estolide esters show superior low-temperature properties (-52 ± 0.08°C) and high flash po...

A high yielding rearrangement of epoxy-esters, under Lewis acid conditions, to give bicyclic ortho esters is reported.

Subsequent to phytochemical investigation on scutellaria lateriflora (Labiatae) from Mazandaran provincein Iran, the wax ester fraction of the leaves has been investigated. Using TLC, CC GLC and GLC-MS, the alkyl esters of the epicuticular wax was analysed. Total concentration of the esters was 35% and it was shown to be composed of a homologous series having various chain lengths in the ra...