نتایج جستجو برای: esle app

تعداد نتایج: 23489  

Journal: :BMC complementary and alternative medicine 2016
Hye Jeong Yang Min Jung Kim Dae Young Kwon Bo Reum Moon A Reum Kim Suna Kang Sunmin Park

BACKGROUND Artemisia princeps Pamp (APP), Leonurus japonicas Houtt (LJH), and Gardenia jasminoides Ellis fruit (GJE) have been traditionally used in East Asia to treat women's diseases related to reproductive system. They may attenuate the deterioration of energy, lipid, glucose and bone metabolism by estrogen deficiency. The present study explored the combination of APP, LJH, and GJE to overco...

2014
Dolores Del Prete Franco Lombino Xinran Liu Luciano D'Adamio Masuo Ohno

Amyloid Precursor Protein (APP) is a type I membrane protein that undergoes extensive processing by secretases, including BACE1. Although mutations in APP and genes that regulate processing of APP, such as PSENs and BRI2/ITM2B, cause dementias, the normal function of APP in synaptic transmission, synaptic plasticity and memory formation is poorly understood. To grasp the biochemical mechanisms ...

2012
Janet C MacKinnon Patricia Huether Bettina E Kalisch

We determined previously that nitric oxide (NO) modulates the nerve growth factor (NGF)-mediated increases in amyloid precursor protein (APP) levels in PC12 cells. To elucidate potential mechanisms, the effects of NGF and NO synthase (NOS) inhibitors on APP mRNA levels and protein stability were evaluated. Surprisingly, treatment of PC12 cells with NGF resulted in decreased levels of APP695 and...

Journal: :The Journal of biological chemistry 2012
Justin M Long Balmiki Ray Debomoy K Lahiri

Regulation of amyloid-β (Aβ) precursor protein (APP) expression is complex. MicroRNAs (miRNAs) are expected to participate in the molecular network that controls this process. The composition of this network is, however, still undefined. Elucidating the complement of miRNAs that regulate APP expression should reveal novel drug targets capable of modulating Aβ production in AD. Here, we investig...

2014
Aurélie Hendrickx Nathalie Pierrot Bernadette Tasiaux Olivier Schakman Pascal Kienlen-Campard Charles De Smet Jean-Noël Octave

We previously demonstrated that APP epigenetically regulates Egr1 expression both in cultured neurons and in vivo. Since Egr1 is an immediate early gene involved in memory formation, we wondered whether other early genes involved in memory were regulated by APP and we studied molecular mechanisms involved. By comparing prefrontal (PF) cortex from wild type (APP+/+) and APP knockout mice (APP-/-...

Journal: :Electronic Colloquium on Computational Complexity (ECCC) 2000
Valentine Kabanets Charles Rackoff Stephen A. Cook

We define a class, denoted APP, of real-valued functions f : {0, 1}n → [0, 1] such that f can be approximated to within any > 0 by a probabilistic Turing machine running in time poly(n, 1/ ). The class APP can be viewed as a generalization of BPP. We argue that APP is more natural and more important than BPP, and that most results about BPP are better stated as results about APP. We show that A...

2016
Ji-Seon Park Dong-Hou Kim Seung-Yong Yoon

Understanding of trafficking, processing, and degradation mechanisms of amyloid precursor protein (APP) is important because APP can be processed to produce β-amyloid (Aβ), a key pathogenic molecule in Alzheimer's disease (AD). Here, we found that APP contains KFERQ motif at its C-terminus, a consensus sequence for chaperone-mediated autophagy (CMA) or microautophagy which are another types of ...

Journal: :The Journal of Cell Biology 2003
Nicole LeBrasseur

To kill a brain cell he consequences of amyloid formation by the amyloid precursor protein (APP) in Alzheimer's disease (AD) have been the focus of many studies, yet little is known about the nonpathogenic function of APP. On page 27, some progress is made in this direction by Chen et al., who show that APP induces a suicide pathway in neurons. APP initiates this death-inducing cascade when it ...

Journal: :The Journal of Cell Biology 2003
Robert Ehehalt Patrick Keller Christian Haass Christoph Thiele Kai Simons

Formation of senile plaques containing the beta-amyloid peptide (A beta) derived from the amyloid precursor protein (APP) is an invariant feature of Alzheimer's disease (AD). APP is cleaved either by beta-secretase or by alpha-secretase to initiate amyloidogenic (release of A beta) or nonamyloidogenic processing of APP, respectively. A key to understanding AD is to unravel how access of these e...

Journal: :Neuro-degenerative diseases 2006
Stefan Kins Nadine Lauther Anita Szodorai Konrad Beyreuther

Changes in the intracellular transport of amyloid precursor protein (APP) affect the extent to which APP is exposed to alpha- or beta-secretase in a common subcellular compartment and therefore directly influence the degree to which APP undergoes the amyloidogenic pathway leading to generation of beta-amyloid. As the presynaptic regions of neurons are thought to be the main source of beta-amylo...

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