Indiscriminate and excessive uses of antibiotics may be lead promote the emergence of antibiotic-resistant microorganisms and side effects in patients. Therefore the researchers recently have focused on the use of natural resources, especially medicinal plants. Ruta graveolens is a kind of medical plants which contains antifungal and antibacterial components and use in traditional medicine in I...

LacI gene encodes for the repressor of Lac operon. An Esherichia coli (E. coli) strain with a lacI knockout would yield cells that can constitutively express ß-galactosidase. Use of these cells can considerably reduce the use on an inducer isopropyl-ß-D-1-thiogalactoside (IPTG) and reduce the induction time. Jaeger et al (2) prepared a presumptive lacI knockout in E. coli C29 strain using a λ R...

Background-E.coli is found to be the commonest cause of UTI. However E. coli antibiotic resistance has escalated over the past many years. ObjectiveTo provide an update of prevalence of multidrug resistant E.coli isolates and their antibiotic susceptibility pattern with special reference to northern region of Chandigarh. MethodsThis retrospective study was conducted in the Department of Microbi...

Microbial hydroxylation of progesterone occurred in the culture of Acremonium strictum PTCC 5282 to produce two hydroxylated pregnene-like steroids. The metabolites were purified and characterized using spectroscopic methods and identified as 15alpha-hydroxyprogesterone and 15alpha-hydroxydeoxycorticosterone.

a Department of Geological Sciences, University of North Carolina at Chapel Hill, 104 South Rd., Mitchell Hall, CB #3315, Chapel Hill, NC 27599-3315, USA b Department of Terrestrial Magnetism, Carnegie Institution for Science, 5241 Broad Branch Road, NW, Washington, DC 20015-1305, USA c Department of Geosciences, University of Arizona, 1040 E. 4th Street, Tucson, AZ 85721, USA d Department of G...

Food and feedstuff contamination with aflatoxins (AFTs) is a serious health problem for humans and animals, especially in developing countries. The present study evaluated antifungal activities of two lactic acid bacteria (LAB) against growth and aflatoxin production of toxigenic Aspergillus parasiticus. The mycelial growth inhibition rate of A. parasiticus PTCC 5286 was investigated in the pre...

Heterocyclic compounds containing a pyrimidine nucleus are of special interests due to their applications in medicinal chemistry as they are the basic skeleton of several bioactive compounds such as antifungal, antibacterial, antitumor and antitubercular. As a part of our research in the synthesis of pyrimidine derivatives containing biological activities, some new tetrahydropyrimidine derivati...

Background & Aim: Platychaete aucheri (Boiss.) Boissis one of the Persian endemic plants and it belongs to Asteraceae family. The present study was aimed to evaluate the antimicrobial activity of crude methanolic extract and three sub-fractions of the flowering aerial parts of Platychaete aucheri against some gram-positive and gram-negative standard b...