نتایج جستجو برای: esat6
تعداد نتایج: 122 فیلتر نتایج به سال:
Improved methods are required for the early and accurate diagnosis of tuberculosis, especially in the patients with smear-negative disease. Several biomarkers have been tried but most have shown poor sensitivity or specificity. In present study we aimed to evaluate the diagnostic utility of five novel antigens identified earlier by us. This is an initial study conducted on 250 subjects. The fiv...
BACKGROUND Diagnosis and treatment monitoring of patients with tuberculosis remain challenging. OBJECTIVE We have evaluated whether Mycobacterium-specific interferon (IFN)-γ and interleukin (IL)-2 bifunctional cytokine immune response assays improve the diagnosis of and correlate to treatment response in pulmonary tuberculosis. METHODS Early secretory antigenic target (ESAT)6/culture filtra...
There is a paucity of data on the pulmonary immune-compartment interferon gamma (IFNγ) response to M. tuberculosis, particularly in settings of high tuberculosis (TB) prevalence and in HIV-coinfected individuals. This data is necessary to understand the diagnostic potential of commercially available interferon gamma release assays (IGRAs) in both the pulmonary immune-compartment and peripheral ...
Effective tuberculosis (TB) vaccine should target tubercle bacilli with various metabolic states and confer long-term protective immunity. In this study, we constructed a novel multi-stage TB subunit vaccine based on fusion protein ESAT6-Ag85B-MPT64(190-198)-Mtb8.4-HspX (LT69 for short) which combined early expressed antigens and latency-associated antigen. The fusion protein was mixed with an ...
Data on the role of regulatory T lymphocytes (Treg) in immunopathogenesis tuberculosis are actively accumulating current literature. The overwhelming effect Treg cells proliferation, functional activity Th1 and antigen-presenting allows to consider this population as a possible target modulation immune response patients with tuberculosis. Notch signaling pathway participates regulation FoxP3 tr...
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