Sensitive strains of Staphylococcus aureus can acquire resistance to all three of the antibiotics erythromycin, oleandomycin, and spiramycin when grown in culture media containing subinhibitory concentrations of any one of them (Jones, Nichols, and Finland, 1956). In contrast with the uniform pattern of resistance to the tetracyclines, however, staphylococci isolated from patients are often des...

Keller and Morton (1953) first discovered the treponemicidal properties of erythromycin and Turner and Schaeffer (1954) showed that erythromycin came second to penicillin as the most active antibiotic against Treponema pallidum. Kolmer and Rule (1956) attributed treponemicidal properties to erythromycin, but obtained superior results with several other antibiotics. Alexander and Schoch (1954) t...

Since the late 1990s, the prevalence of erythromycin-resistant Streptococcus pyogenes has significantly increased in several European countries. Between January 1999 and December 2002, 1,577 isolates of S. pyogenes were recovered from children with tonsillopharyngitis living in various areas of Western Greece. Erythromycin resistance was observed in 379 (24%) of the 1,577 isolates. All erythrom...

Erythromycin A(1)inhibits the growth of bacteria by blocking protein synthesis.1) The antibiotic acts by specifically binding to 50 S ribosomes in both Gram-positive(Bacillus2)and Staphylococcus3)) and Gram-negative(Eschericihac4))bacteria. In cell free preparations, the binding occurs at very low erythromycin concentrations and about one molecule of erythromycin is bound per 50 S ribosome.3・4)...

Acne is a common inflammatory skin disease that mainly affects the face, neck, chest and upper back. Treatment depends on severity. Erythromycin has bacteriostatic activity which inhibits the growth of bacteria. They mainly act by binding to the 50s subunits of bacteria, 70s r-RNA complex, and protein synthesis. Erythromycin is also used topically to treat acne. They are used to treat moderate ...

BACKGROUND Erythromycin, a hydrophobic antibiotic used to treat infectious diseases, is now gaining attention because of its anti-inflammatory effects and ability to inhibit osteoclasts formation. The aim of this study was to explore a cyclodextrin-erythromycin (CD-EM) complex for sustained treatment of orthopedic inflammation. METHODS AND RESULTS Erythromycin was reacted with β-cyclodextrin ...

Translation of a 5-codon mini-gene encoded in Escherichia coli 23 S rRNA was previously shown to render cells resistant to erythromycin (Tenson, T., DeBlasio, A., and Mankin, A. S. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 5641-5646). Erythromycin resistance was mediated by a specific interaction of the 23 S rRNA-encoded pentapeptide with the ribosome. In the present study, peptides conferring...

An 8.1-kb region of the Saccharopolyspora erythraea genome, significant for its contiguity to the known genes of the erythromycin biosynthetic gene cluster, was mutationally analyzed and its DNA sequence was determined. The region lies immediately adjacent to eryCI. The newly characterized region is notable for a large, 3.0-kb segment, predicted not to be translated, followed by four probable g...

To assess the efficacy of oral erythromycin in the treatment of nonspecific vaginitis (NSV), conducted a nonrandom, unblinded pilot study among 17 women with symptoms and signs of NSV. At the completion of treatment, 10 of 13 patients had persistent symptoms, 9 of 13 had persistent abnormal discharge, and 11 of 13 had persistently positive cultures for Haemophilus vaginalis. Ten patients with p...