نتایج جستجو برای: erns
تعداد نتایج: 194 فیلتر نتایج به سال:
E(rns) is an essential virion glycoprotein with RNase activity that suppresses host cellular innate immune responses upon being partially secreted from the infected cells. Its unusual C-terminus plays multiple roles, as the amphiphilic helix acts as a membrane anchor, as a signal peptidase cleavage site, and as a retention/secretion signal. We analyzed the structure and membrane binding propert...
The pestivirus envelope glycoprotein E(rns) has RNase activity and therefore was suspected to enter cells to cleave RNA. The protein contains an RNase domain with a C-terminal extension, which shows homology with a membrane-active peptide. The modular architecture and the C-terminal homology suggested that the C terminus could be responsible for the presumed translocation. Peptides correspondin...
E(rns) is a structural glycoprotein of pestiviruses found to be attached to the virion and to membranes within infected cells via its COOH terminus, although it lacks a hydrophobic anchor sequence. The COOH-terminal sequence was hypothesized to fold into an amphipathic alpha-helix. Alanine insertion scanning revealed that the ability of the E(rns) COOH terminus to bind membranes is considerably...
The development of e-health technologies for teleconsultation and exchange knowledge is within the mission European Reference Networks (ERN), including Euro-NMD, ERN rare neuromuscular diseases. Clinical Patient Management System (CPMS) a web-based platform promoting active collaboration across ERNs to discuss patient cases. “Telegenetics” represents an attractive alternative traditional on-sit...
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