نتایج جستجو برای: erk signaling pathway

تعداد نتایج: 529727  

Journal: :American journal of physiology. Cell physiology 2006
Karni S Moshal Utpal Sen Neetu Tyagi Brooke Henderson Mesia Steed Alexander V Ovechkin Suresh C Tyagi

Homocysteine (Hcy) induces matrix metalloproteinase (MMP)-9 in microvascular endothelial cells (MVECs). We hypothesized that the ERK1/2 signaling pathway is involved in Hcy-mediated MMP-9 expression. In cultured MVECs, Hcy induced activation of ERK, which was blocked by PD-98059 and U0126 (MEK inhibitors). Pretreatment with BAPTA-AM, staurosporine (PKC inhibitor), or Gö6976 (specific inhibitor ...

Journal: :Cancer research 2006
Michael Schümann Matthias Dobbelstein

The Raf/mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK signaling cascade enhances tumor cell proliferation in many cases. Here, we show that adenovirus type 5, a small DNA tumor virus used in experimental cancer therapy, strongly induces ERK phosphorylation during the late phase of infection. Pharmacologic inhibition of ERK phosphorylation reduced virus r...

Journal: :Biochemical and Biophysical Research Communications 2018

Journal: :Journal of Biology 2006
Alison C Lloyd

The Ras/Raf/MEK/ERK signaling pathway is one of the best understood signal routes in cells. Recent studies add complexity to this cascade by indicating that the two ERK kinases, ERK1 (p44ERK1) and ERK2 (p42ERK2), may have distinct functions.

Journal: :Learning & memory 2013
Ashley M Fortress Lu Fan Patrick T Orr Zaorui Zhao Karyn M Frick

The mammalian target of rapamycin (mTOR) signaling pathway is an important regulator of protein synthesis and is essential for various forms of hippocampal memory. Here, we asked whether the enhancement of object recognition memory consolidation produced by dorsal hippocampal infusion of 17β-estradiol (E(2)) is dependent on mTOR signaling in the dorsal hippocampus, and whether E(2)-induced mTOR...

2017
Mark Merchant John Moffat Gabriele Schaefer Jocelyn Chan Xi Wang Christine Orr Jason Cheng Thomas Hunsaker Lily Shao Stephanie J Wang Marie-Claire Wagle Eva Lin Peter M Haverty Sheerin Shahidi-Latham Hai Ngu Margaret Solon Jeffrey Eastham-Anderson Hartmut Koeppen Shih-Min A Huang Jacob Schwarz Marcia Belvin Daniel Kirouac Melissa R Junttila

Mitogen-activated protein kinase (MAPK) pathway dysregulation is implicated in >30% of all cancers, rationalizing the development of RAF, MEK and ERK inhibitors. While BRAF and MEK inhibitors improve BRAF mutant melanoma patient outcomes, these inhibitors had limited success in other MAPK dysregulated tumors, with insufficient pathway suppression and likely pathway reactivation. In this study w...

Journal: :International Journal of Molecular Sciences 2020

Journal: :PLoS ONE 2008
Takashi Nakakuki Noriko Yumoto Takashi Naka Mikako Shirouzu Shigeyuki Yokoyama Mariko Hatakeyama

Ligand-induced homo- and hetero-dimer formation of ErbB receptors results in different biological outcomes irrespective of recruitment and activation of similar effector proteins. Earlier experimental research indicated that cells expressing both EGFR (epidermal growth factor receptor) and the ErbB4 receptor (E1/4 cells) induced E1/4 cell-specific B-Raf activation and higher extracellular signa...

2012
Zhiyong Deng Guangchao Sui Paulo Mottin Rosa Weiling Zhao

Radiation-induced normal brain injury is associated with acute and/or chronic inflammatory responses, and has been a major concern in radiotherapy. Recent studies suggest that microglial activation is a potential contributor to chronic inflammatory responses following irradiation; however, the molecular mechanism underlying the response of microglia to radiation is poorly understood. c-Jun, a c...

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