نتایج جستجو برای: ergot
تعداد نتایج: 1627 فیلتر نتایج به سال:
Ergot alkaloids and their derivatives are able to inhibit the growth of certain hormone-dependent tumors via the inhibition of prolactin release from the anterior pituitary gland (Cassady and Floss, 1977). The therapy of the prolactinoma, an adenoma of this gland, and other prolactin-producing tumors by e.g. bromokryptine or lisuride is of clinical relevance (Thorner et al., 1980). The inhibiti...
This manuscript reviews the history and pharmacognosy of ergot, and describes the isolation/preparation, chemistry, pharmacodynamics, and pharmacotherapeutics of the major ergot alkaloids and their derivatives. A brief discussion of the hallucinogenic properties of lysergic acid diethylamide is also featured. An abbreviated form of the material found in this paper is presented in a 4-hour didac...
The ergot alkaloids, a class of fungal-derived natural products with important biological activities, are derived from a common intermediate, chanoclavine-I, which is elaborated into a set of diverse structures. Herein we report the discovery of the biosynthetic pathway of cycloclavine, a complex ergot alkaloid containing a cyclopropyl moiety. We used a yeast-based expression platform along wit...
Cafergot is a widely used migraine abortive medication. It is a preparation containing ergotamine tartrate 1mg and caffeine 100 mg. Ergotism is one of rare serious side effects of ergot-based drugs such as ergotamine. Ergotism is defined as an intense arterial vasoconstriction, producing signs and symptoms of peripheral vascular ischemia such as numbness, tingling and pain in the extremities, c...
A patient with ergot intoxication due to medication for migraine developed lateral popliteal nerve palsy. This is attributed to recurrent ischaemia caused by ergotamine.
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