Vitamin D1 Compound of ergocalciferol with lumisterol (stereoisomer of ergosterol) 1:1 ratio Vitamin D2 Ergocalciferol (made from ergosterol) Vitamin D3 Cholecalciferol (made from 7dehydrocholesterol in the skin) Vitamin D4 22-dihydroergocalciferol Vitamin D5 Sitocalciferol (made from 7-dehydrositosterol) Vitamin D6 Calciferol 25-(OH) Vitamin D Calcidiol or calcifediol; indicates no distinction...

The in vitro activities of liposome-encapsulated amphotericin B and free amphotericin B against Candida albicans 336 were comparable. Amphotericin B concentrations 12-fold and greater than 50-fold higher were required to kill the same organism when cholesterol and ergosterol were incorporated into the liposomes. The addition of cholesterol to liposomes caused a significant increase in the minim...

A novel co-regulation exists between the first step of GPI (glycosylphosphatidylinositol) anchor biosynthesis and the rate-determining step of ergosterol biosynthesis in Candida albicans. Depleting CaGpi19p, an accessory subunit of the enzyme complex that initiates GPI biosynthesis, down-regulates ERG11, altering ergosterol levels and drug response. This effect is specific to CaGpi19p depletion...

The antifungal effect of a polyene antibiotic amphotericin B (AMB) was almost completely abrogated by exogenous addition of 0.1 microgram/ml ergosterol in the medium. The cytocidal effect of AMB on Saccharomyces cerevisiae was synergistically enhanced when cultured for more than 4 hours with squalene, an obligatory intermediate molecule for sterol formation. However, we could not find significa...

The mechanism of action of efinaconazole, a new triazole antifungal, was investigated with Trichophyton mentagrophytes and Candida albicans. Efinaconazole dose-dependently decreased ergosterol production and accumulated 4,4-dimethylsterols and 4α-methylsterols at concentrations below its MICs. Efinaconazole induced morphological and ultrastructural changes in T. mentagrophytes hyphae that becam...

Ajuga remota is the most frequently used medicinal herb for malaria treatment in Kenya. Its two known isolates ajugarin-1 (1) and ergosterol-5,8-endoperoxide (3) and a new isolate 8-O-acetylharpagide (2) were evaluated for their in vitro antiplasmodial activity. Ajugarin-1 was moderately active, with an IC(50) of 23.0 +/- 3.0 microM, as compared to chloroquine (IC(50) = 0.041 +/- 0.003 microM) ...

This paper deals with the effect of Tween 80 and ergosterol supplementation to the 24oPt wort with 30% maltose syrup adjunct on the fermentation performance of the immobilized yeast in calcium alginate gel. The higher the content of supplements in the wort, the higher the yeast growth, the sugar and free amino nitrogen consumption rates and the ethanol production rate but the lower the ethanol ...

Different fungi are discussed to play a certain role in recent spruce decline in addition to different abiotic factors such as S 0 2, photooxidants (ozone) or unfavourable climatic conditions. Thus, ergosterol as a specific fungal sterol was used as a biochemical indicator for fungal infection in differently damaged spruce and fir needles. With its aid it could be demonstrated that the importan...