Abstract Background Invasive micropapillary carcinoma (IMPC) is a rare malignant breast tumor and variant form of invasive ductal that an aggressive neoplasm the human canine mammary gland. The importance microenvironment in cancer development has gradually been recognized, but little known about cell types outlining cystic space IMPC. This study aimed to characterize neoplastic cells Results I...

Malignant phyllodes tumors of the breast are aggressive, occurring less frequently than fibroadenomas. The diagnosis is established after excluding metaplastic carcinoma and sarcomas. A 47 year old woman presented a primary tumor composed of hyperplastic epithelial and mucoid component, typically seen in fibroadenomas. Further investigations revealed PanCK, EMA and CK8/18 stained epithelial cel...

We have demonstrated and localized human GH (hGH) gene expression in surgical specimens of normal human mammary gland and in proliferative disorders of the mammary gland of increasing severity using sensitive in situ RT-PCR methodology. hGH mRNA identical to pituitary hGH mRNA was first detected by RT-PCR of RNA derived from samples of normal human mammary gland. Cellular localization of hGH ge...

Epithelial-myoepithelial carcinoma (EMC) of the lung is rare and is considered to be low-grade malignancy. Intracranial metastasis of pulmonary EMC has not previously been reported according to our search of the literature. We report a case of skull metastasis as the initial manifestation of pulmonary EMC. An 81-year-old man complained of left leg motor weakness. Neurological examination showed...

Myoepithelial tumors of the soft tissues represent a rare group of neoplasms that vary in their clinical behavior, pathologic features and genetics. They are histopathologically typified by a myoepithelial immunohistochemical phenotype, of expression of one or more epithelial markers, S100 protein and smooth muscle actin. Because of their rarity and occurrence over a wide age range and at a var...

Myoepithelial-epithelial carcinoma (MEC) is a low malignancy grade neoplasia which has a prevalence of 1% to 2% among all primary tumors of the salivary gland. It has a higher incidence at 60 years of age. About 60% of the patients are females. The parotid gland is the most often reported anatomical site; nonetheless, other sites have been reported, such as the submandibular gland, minor saliva...