An important contributor to the generation of epileptiform activity is the synchronization of burst firing in a group of neurons. The aim of this study was to investigate whether gap junctions are involved in this synchrony using an in vitro model of epileptiform activity. Hippocampal slices (400 mm) were prepared from female Sprague–Dawley rats (120–170 g). The perfusion of slices with a mediu...

Astrocytes are integral functional components of synapses, regulating transmission and plasticity. They have also been implicated in the pathogenesis of epilepsy, although their precise roles have not been comprehensively characterized. Astrocytes integrate activity from neighboring synapses by responding to neuronally released neurotransmitters such as glutamate and ATP. Strong activation of a...

To investigate the spatiotemporal properties of epileptiform activity in vitro, 400 microm-thick transverse hippocampal slices were prepared from juvenile rat and planar multi-electrode array (MEA) containing 60 electrodes was used to record the electrical activity induced by bath application of high potassium artificial cerebrospinal fluid (ACSF) on slices. Following successful induction of ep...

This paper outlines a novel approach to wavelet based detection of epileptiform activity in the EEG. A special complex-valued wavelet filter is used in a continuous wavelet transform (CWT). The response of wavelet coefficients (WCs) to epileptiform discharges (EDs) is measured with respect to artifact-free background activity (BG). A detector based on the WCs of a single scale could operate at ...

1 2 Suppression of epileptiform activity by a single short-duration electric field in 3 rat hippocampus in vitro 4 5 Ronni Mikkelsen, Mogens Andreasen and Steen Nedergaard 6 Department of Biomedicine, Aarhus University, DK-8000 Aarhus C, Denmark. 7 8 9 10 11 Running title: Suppression of epileptiform activity by electric field 12 13 14 Address for correspondence: Steen Nedergaard, Department of...

In a prospective study of consecutive patients (age 15 or over) with transient loss of consciousness 45 patients had a history of seizure and 74 patients had a history of syncope. All patients had an EEG, ECG, laboratory tests and a hyperventilation test and were followed for an average of 14.5 months. Epileptiform activity in the interictal EEG had a sensitivity of 0.40 and a specificity of 0....

OBJECTIVE To investigate the effects of thymoquinone (TQ) in a penicillin-induced epilepsy model in rats. METHODS This experimental study included 56 adult male Wistar rats. Experiments were performed in the Research Laboratory of the Department of Physiology, Medical School, Duzce University, Duzce, Turkey, between October 2013 and December 2014. Animals were divided into the following 7 gro...

OBJECTIVES To assess the frequency of electroencephalogram (EEG) requests in the emergency room (ER) and intensive care unit (ICU) for patients with impairment of consciousness (IC) and its impact in the diagnosis and management. METHODS We followed patients who underwent routine EEG from ER and ICU with IC until discharge or death. RESULTS During the study, 1679 EEGs were performed, with 1...

BACKGROUND According to recent clinical findings epileptiform activity in temporolimbic structures may cause depressive and other psychiatric symptoms that may occur independently of any seizure in patient's history. In addition in these patients subclinical seizure-like activity with indirect clinical manifestations likely may occur in a form of various forms of cognitive, affective, memory, s...