Sol-gel entrapment is an efficient immobilization technique that allows preparation of robust and highly stable biocatalysts. Lipase from Candida antarctica B was immobilized by sol-gel entrapment and by sol-gel entrapment combined with adsorption on Celite 545, using a ternary silane precursor system. After optimization of the immobilization protocol, the best enzyme loading was 17.4 mg/g supp...

Response surface methodology (RSM) was used to optimize the process of preparing bovine serum albumin (BSA) nanoparticles by desolvation, then the resulting BSA nanoparticles (BSANPs) were conjugated with folate to produce a drug carrier system that can specifically target tumors. The anticancer drug, vinblastine sulfate (VBLS), was loaded to this tumor-specific drug carrier system for the purp...

The aim of this investigation was to prepare, characterize and optimize the vinblastine sulphate loaded proniosomes for overall improvement in the physical stability and to prolong the release time in a controlled manner there by increasing its efficacy and to reduce its toxicity and to study the suitability of proniosomes as the carrier of drug. Proniosomes of vinblastine sulphate were prepare...

This research focuses on the development of enteric microparticles of lansoprazole in a single step by employing the spray drying technique and studies the effects of variegated formulation/process variables on entrapment efficiency and in vitro gastric resistance. Preliminary trials were undertaken to optimize the type of Eudragit and its various levels. Further trials included the incorporati...

OBJECTIVES The objectives of this study were to prepare cyclosporin A (CsA)-containing proliposomes using the supercritical antisolvent (SAS) process and the conventional thin film method for the comparative study of proliposomal formulations and to evaluate the physicochemical properties of these proliposomes. METHODS CsA-containing proliposomes were prepared by the SAS process and the conve...

A new generation of nanostructured lipid carriers (NLCs) consisting of a lipid matrix with a special nanostructure has been developed. This nanostructure improves drug loading and firmly incorporates the drug during storage. Surfactants play important roles in the formation and characterization of nanostructured lipid carriers. In order to investigate the influence of surfactants on properties ...

objective(s) the aim of this study was to formulate and evaluate microencapsulated controlled release preparations of theophylline using ethylcellulose as the retardant material with high entrapment efficiency. materials and methods microspheres were prepared by water-in-oil-in-oil (w/o1/o2) emulsion-solvent diffusion (esd). a mixed solvent system consisting of acetonitrile and dichloromethane ...