نتایج جستجو برای: enos protein

تعداد نتایج: 1236383  

Journal: :Molecular pharmacology 2006
Matthew L Bilodeau Heidi E Hamm

In this issue of Molecular Pharmacology, Andreeva et al. (p. 975) report a novel functional link between the heterotrimeric G protein G alpha12 and endothelial nitric-oxide synthase (eNOS). Based on studies characterizing the interaction of G alpha12 and the molecular chaperone Hsp90 and the interaction of eNOS and Hsp90, the group proposed an interaction between G alpha12 and eNOS and sought t...

2016
Jinhong Li Xiaoming Wang Zhuang Tang Zhenghua Liu Chunxiao Pu Yunjin Bai Yin Tang Qiang Wei Ping Han

Objective: To investigate the effect of histological prostate inflammation on erectile function and its possible mechanism. Methods: After the induction of histological prostate inflammation in Sprague-Dawley (SD) rats, the erectile function, ratio of maximum intracavernosal pressure (ICP)/mean arterial pressure (MAP), enzyme activity of endothelial nitric oxide synthase (eNOS), cyclic guanosin...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2001
J Martínez-González B Raposo C Rodríguez L Badimon

Atherogenic levels of native low density lipoproteins (nLDLs) decrease the bioavailability of endothelium-derived NO and downregulate endothelial NO synthase (eNOS) expression in cultured human endothelial cells. Here, we show that simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, within the therapeutic range (0.01 to 1 micromol/L) prevented the downregulation of eNOS mR...

2015
Qiuhua Zhang Youde Jiang Jena J. Steinle

PURPOSE In models of diabetic retinopathy, insulin-like growth factor binding protein-3 (IGFBP-3) is protective to the retina, especially retinal microvascular endothelial cells (RECs), but the underlying mechanisms are unclear. For this study, we hypothesized that IGFBP-3 may reduce vascular endothelial growth factor (VEGF) levels through reduced endothelial nitric oxide synthase (eNOS) activi...

Journal: :The Journal of pharmacology and experimental therapeutics 1999
R J Hendrickson P A Cahill J V Sitzmann E M Redmond

The aim of this study was to determine the effect of ethanol on endothelial nitric oxide synthase (eNOS), the enzyme responsible for the production of the important vasoactive agent nitric oxide. The effect of ethanol (0.8-160 mM) on both basal and flow-stimulated eNOS activity was determined using cultured bovine aortic endothelial cells (EC). In "static" EC ethanol dose-dependently increased ...

Journal: :Clinical chemistry 2010
Simona Valleggi Sridevi Devaraj Mohan R Dasu Ishwarlal Jialal

BACKGROUND C-reactive protein (CRP) inhibits the activity of the endothelial isoform of nitric oxide synthase (eNOS) via uncoupling of the enzyme both in vitro and in vivo. eNOS activity appears to be related in part to its interaction with other cellular proteins, including heat shock protein 90 (Hsp90), caveolin-1, and porin. In this study, we examined the effect of CRP treatment of human aor...

2014
Hongtao Liu Shujie Yu Hua Zhang Jian Xu

The 26S proteasome plays a fundamental role in almost all eukaryotic cells, including vascular endothelial cells. However, it remains largely unknown how proteasome functionality is regulated in the vasculature. Endothelial nitric oxide (NO) synthase (eNOS)-derived NO is known to be essential to maintain endothelial homeostasis. The aim of the present study was to establish the connection betwe...

Journal: :Circulation 2001
G Kojda Y C Cheng J Burchfield D G Harrison

BACKGROUND Previous data suggest that 1 endothelial NO synthase (eNOS) gene is sufficient to allow normal expression and function of eNOS under basal conditions. We hypothesized that this might not hold true for conditions known to increase eNOS gene expression, such as exercise. METHODS AND RESULTS Male mice heterozygous for a disruption of the eNOS gene (eNOS(+/)(-)) and normal C56Bl/6J mic...

Journal: :Journal of applied physiology 2001
M H Laughlin J S Pollock J F Amann M L Hollis C R Woodman E M Price

Exercise training produces enhanced nitric oxide (NO)-dependent, endothelium-mediated vasodilator responses of porcine coronary arterioles but not conduit coronary arteries. The purpose of this study was to test the hypothesis that exercise training increases the amount of endothelial NO synthase (eNOS) in the coronary arterial microcirculation but not in the conduit coronary arteries. Miniatur...

2008
Guijun Yan Bei You Shao-Ping Chen James K. Liao Jianxin Sun

Endothelium-derived nitric oxide (NO) is an important regulator of vascular function. NO is produced by endothelial NO synthase (eNOS), whose expression is downregulated by tumor necrosis factor (TNF)at the posttranscriptional level. To elucidate the molecular basis of TNF–mediated eNOS mRNA instability, eNOS 3 untranslated region (3 -UTR) binding proteins were purified by RNA affinity chromato...

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