The solution to the canonical problem of a radiating infinitesimal electric dipole antenna that is centred in a multilayered, concentric metamaterial-based spherical shell system is presented. It is demonstrated that when this system is electrically small, a specifically designed homogenous and isotropic epsilon-negative (ENG) layer can function as a distributed matching element to the antenna ...

OBJECTIVE To determine if angiogenesis is altered in adult Endoglin heterozygous (Eng(+/-)) mice, the animal model for the vascular disorder hereditary hemorrhagic telangiectasia type 1 (HHT1). METHODS Primary cultures of endothelial cells were generated from Eng(+/-) and Eng(+/+) mice and analyzed for proliferation, migration, and ability to form capillary-like tubes. Endothelial cells deriv...

Endoglin (ENG), an ancillary receptor for several members of the transforming growth factor (TGF)-beta superfamily, has a well-studied role in endothelial function. Here, we report that endoglin also plays an important role early in development at the level of the hemangioblast, an embryonic progenitor of the hematopoietic and endothelial lineages. Eng(-/-), Eng(+/-) and Eng(+/+) mouse embryoni...

BACKGROUND AND PURPOSE Endoglin deficiency causes hereditary hemorrhagic telangiectasia-1 and impairs myocardial repair. Pulmonary arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia-1 are associated with a high incidence of paradoxical embolism in the cerebral circulation and ischemic brain injury. We hypothesized that endoglin deficiency impairs stroke recovery....

Quantitative analysis of protein biomarkers in plasma is typically done by ELISA, but this method is limited by the availability of high-quality antibodies. An alternative approach is protein immunoprecipitation combined with multiple reaction monitoring mass spectrometry (IP-MRM). We compared IP-MRM to ELISA for the analysis of six colon cancer biomarker candidates (metalloproteinase inhibitor...

As a continuous effort to develop automated methods for predicting membrane protein types that was initiated by Chou and Elrod (PROTEINS: Structure, Function, and Genetics, 1999, 34, 137-153), the support vector machine (SVM) is introduced. Results obtained through re-substitution, jackknife, and independent data set tests, respectively, have indicated that the SVM approach is quite a promising...

BACKGROUND AND PURPOSE A 6-base insertion (6bINS) polymorphism in intron 7 of the endoglin gene (ENG), which codes for a component of the transforming growth factor-beta receptor complex, was reported to be associated with intracranial aneurysm (IA) in a Japanese population. A recent report using a white population could not replicate the association. We tested for this association with high st...

1Associate Member of ASCE, Ph.D., Assoc. Professor, Dept. of Civil and Env. Eng., Stanford Univ., and Director, Center for Integrated Facility Engineering (Terman Eng. Ctr., 380 Panama Mall, Stanford, CA 94305-4020, USA) E-mail:[email protected] 2Ph.D., Sr. Research Scientist, Dept. of Civil and Env. Eng., Stanford Univ. and Executive Director, Center for Integrated Facility Engineering (CIF...

Electrical Substrate Elimination in 135 Consecutive Patients With Brugada Syndrome Carlo Pappone, MD, PhD; Josep Brugada, MD, PhD; Gabriele Vicedomini, MD; Giuseppe Ciconte, MD; Francesco Manguso, MD, PhD; Massimo Saviano, MD; Raffaele Vitale, MD; Amarild Cuko, MD; Luigi Giannelli, MD; Zarko Calovic, MD; Manuel Conti, MD; Paolo Pozzi, Eng; Andrea Natalizia, PhD, Eng; Simonetta Crisà, Eng; Valer...