For the past few centuries, the biological sources of terrestrial origin have been explored and exploited for bioactive metabolites. This has resulted in the stagnancy of discovering either novel compounds or compounds with novel bioactivities. Thus, researchers across the globe have started exploring our big Oceans, for the search of bioactive metabolites. During the past few decades, the rese...

Protease activity of actinomycetes isolated from various soil types of Georgia has been studied. Protease activity strains have been identified among mesophilic and extremophilic actinomycetes. Some strains of mesophilic, alkaliphilic and halophilic actinomycetes are characterized by alkaline protease activity. Their pH optimum for enzyme activity is 10-11. Strains of mesophilic actinomycetes: ...

Marine microorganisms widely distributed on our oceans of the earth and emerging as the great source for the discovery of natural products. Marine Actinomycetes are virtually unlimited sources of novel compounds with many therapeutic applications and hold a prominent position due to their diversity and proven ability to produce novel bioactive compounds. Actinomycetes represent a high proportio...

Actinomycetes (Actinobacteria) are highly attractive as cell factories or bioreactors for applications in industrial, agricultural, environmental, and pharmaceutical fields. Genome sequencing of several species of actinomycetes has paved the way for biochemical and structural analysis of important proteins and the production of such proteins as recombinants on a commercial scale. In this regard...

We have isolated fifty-two endophytic fungi (AA-CRL-1 to AA-CRL52) from the leaves of Catharanthus roseus plants collected from different parts of Pune (Maharashtra, India). These endophytic fungi represented different genera and were screened for vinca alkaloids production using TLC and ESI-MS analysis. Out of the 52 endophytic fungal cultures screened, the endophytic culture AA-CRL-20 was fou...

Endophytic fungi were isolated from the inner bark of Ventilago madrasapatna, a wellknown medicinal plant of India. It was investigated for endophytic mycoflora as a possible source of bioactive secondary metabolites. A total 66 isolates of 14 species belongs to 5 classes, were studied adopting a standard isolation protocol. The colonization frequency of the endophytic fungi was reported as 87....

Endophytic Sporosarcina aquimarina SjAM16103 was isolated from the inner tissues of pneumatophores of mangrove plant Avicennia marina along with Bacillus sp. and Enterobacter sp. Endophytic S. aquimarina SjAM16103 was Gram variable, and motile bacterium measured 0.6-0.9 μm wide by 1.7-2.0 μm long and light orange-brown coloured in 3-day cultures on tryptone broth at 26°C. Nucleotide sequence of...

Over the recent years glutaminase free L-asparaginase has gained more importance due to better therapeutic properties for treatment of acute lymphoblastic leukemia. Actinomycetes are known for L-asparaginase activity. In the current study, 80 actinomycetes were isolated from various soil habitats by serial dilution technique. Presence of L-asparaginase was investigated in a total of 240 actinom...