Lysophosphatidic acid (LPA), a simple phospholipid-derived mediator with diverse biological actions, acts through the specific G protein-coupled receptors endothelial differentiation gene (EDG) 2, EDG4, EDG7, and GPR23. Recent studies indicate a critical role for LPA receptor signaling in embryo implantation. To understand how LPA acts in the uterus during pregnancy in pigs, we evaluated: 1) sp...

To investigate the effects of the frozen embryo transplantation for patients with poor outcome of endometrial growth by using growth hormone intrauterine perfusion combined with replacement cycle in the treatment of non-response thin endometrium. This is a prospective study and study participants were consecutively recruited between Jun 2014 and December 2014. A total of 5 non-response thin end...

background: para-nonylphenol (p-np) is one of the environmental pollutants which cause reproductive system disorders. objective: the effects of vitamin e on ovary structure during its development in rats treated with p-np. materials and methods: 32 wistar female rats after mating were divided into 4 groups; control vitamin e (100mg/kg/day) p-np (250mg/kg/day) and p-np + vitamin e. the rats were...

Background: Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy. This study aims to analyze relationship between changes in vitamin A, E, and oxidative stress levels, pregnancy outcomes GDM patients.

background: vitamin e is an effective antioxidant, protecting cells against oxidative stress. objective: in this investigation the protective effect of vitamin e on the testis during development and spermatogenesis in rats exposed to sodium arsenite was evaluated. materials and methods: pregnant wistar rats were divided into 4 groups (n=8) control, sodium arsenite (8 mg/kg/day), sodium arsenite...

OBJECTIVE To study the ocular hemodynamic effects of a 3-month oral treatment with pentoxifylline in patients with nonexudative age-related macular degeneration. DESIGN Double-blind, placebo-controlled, randomized, parallel group study. SETTING Outpatient clinic of the Department of Ophthalmology, Vienna University, Vienna, Austria, that specializes in age-related macular degeneration. ME...

BACKGROUND In head and neck cancer patients undergoing radiotherapy, osteoradionecrosis (ORN) of the jaw is one of the major but uncommon complications. Satisfactorily results have been observed while treating ORN patients with upcoming treatment modalities such as combination therapy of pentoxifylline and Vitamin E (PVe). It is believed that in patients undergoing dental extractions, these tre...

Purpose : To 1) evaluate the embryotoxic effects of hydrogen peroxide on mouse embryo development and 2) examine if pentoxifylline can reverse hydrogen peroxide induced embryotoxicity. Methods : Prospective in vitro study examining the effects of varying concentrations of hydrogen peroxide and pentoxifylline on the blastocyst development rate alone as well as in combination. Results : A dose-de...

objective: maternal hypovitaminosis d may impair fetal growth and cause adverse pregnancy outcomes including intrauterine growth restriction and neonatal low birth weight. the aim of this study is to evaluate the relationship between maternal vitamin d status and neonate’s birth weight. materials and methods: a cross-sectional, descriptive analytical study was carried out in the nursery ward of...