Nucleolar organizer regions (NORs) are loops of DNA that transcribe to ribosomal RNA. They are associated with nonhistone nucleoproteins which can be stained with silver (AgNORs). The present retrospective study was done to study the efficacy of AgNOR technique in differentiating between non neoplastic and neoplastic lesions of endometrium and to assess the relationship between AgNOR counts and...

  Introduction: The process of discriminating among benign and malignant hyperplasia begun with subjective methods using light microscopy and is now being continued with computerized morphometrical analysis requiring some features. One of the main features called Volume Percentage of Stroma (VPS) is obtained by calculating the percentage of stroma texture. Currently, this feature is calculated ...

The histogenesis, pathogenesis, and endocrine background of endometrial cancer are reviewed. The histogenesis can be traced in graded steps through phases which have been designated as: 1) cystic hyperplasia, 2) adenomatous hyperplasia, 3) ana plasia, and 4) carcinoma in situ. A similar sequence of events has been observed in experimental animals when endometrial cancer was induced by the use o...

Endometrial hyperplasia is of clinical significance because it is often a precursor lesion to adenocarcinoma of the endometrium. Making the distinction between hyperplasia and true precancerous lesions or true neoplasia has significant clinical effect because their differing cancer risks must be matched with an appropriate intervention to avoid undertreatment or overtreatment. Pathologic diagno...

Background: The aim of the conservative treatment is the regression of the hyperplastic to normal endometrium. Conservative treatment of endometrial hyperplasia is based on the administration of agents with either antioestrogenic action or direct anti-proliferative effect on the endometrium. Progestagens have been used widely in the treatment of endometrial hyperplasias. Materials and Methods: ...

Endometrial carcinoma is the second most common gynecological malignancy of the female genital tract worldwide. Enhancer of zeste homolog 2 (EZH2), a critical component of the polycomb repressive complex 2, has been found to be involved in multiple biological processes and is overexpressed in several types of cancer. Previous studies have demonstrated that EZH2 is associated with endometrial ca...

PURPOSE Alteration of CyclinD1 was suggested to relate with development of endometrial carcinogenesis before, however CyclinD1 expression is not well defined in endometrial hyperplasia lesions. We checked the relationship between its expression and clinic-pathological variables of endometrial lesions to explore the possibility for CyclinD1 as a potential diagnostic and prognostic marker. METH...

BACKGROUND This study was designed to evaluate the comparison of insertion of levonorgestrel (LNG)-releasing intrauterine system versus oral medroxyprogesterone acetate on endometrial hyperplasia in a randomized controlled trial. MATERIALS AND METHODS A total of 60 women with the initial histopathological diagnosis of endometrial hyperplasia in two groups received LNG or medroxyprogesterone (...

Background and Objectives: Endometrial hyperplasia (EH) is an abnormal overgrowth of endometrium that may lead to endometrial cancer, especially when accompanied by atypia. The treatment of EH is challenging, and previous studies report conflicting results. Metformin (dimethyl biguanide) is an anti-diabetic and insulin sensitizer agent, which is supposed to have antiproliferative and anticancer...