Endocrine-disrupting chemicals generally function as steroid receptor signaling antagonists or agonists that influence development to promote adult-onset disease. Exposure to the endocrine disruptors during the initiation of male reproductive tract development interferes with the normal hormonal signaling and formation of male reproductive organs. In particular, exposure to the endocrine disrup...

Testing thousands of chemicals to identify potential androgen receptor (AR) agonists or antagonists would cost millions of dollars and take decades to complete using current validated methods. High-throughput in vitro screening (HTS) and computational toxicology approaches can more rapidly and inexpensively identify potential androgen-active chemicals. We integrated 11 HTS ToxCast/Tox21 in vitr...

To investigate the mechanisms underlying motor hyperactivity, we performed intracisternal injection of 6-hydroxydopamine or endocrine disruptors in rats on postnatal day 5. 6-Hydroxydopamine (100 microg, 488 nmol) caused a significant increase in spontaneous motor activities at 4 weeks of age. Gene-expression profiling using a cDNA membrane array revealed alterations in several classes of gene ...

Endocrine disruptor compounds are exogenous agents able to interfere with a gland function, exerting their action across different functional passages, from the synthesis to the metabolism and binding to receptors of the hormone produced. Several issues, such as different levels and time of exposure and different action across different ages as well as gender, make the study of endocrine disrup...

A new position statement from The Endocrine Society provides a strong argument for scientists in industry, government, and academia to work together, across disciplines, to improve testing of chemicals as potential endocrine disruptors. 1 the statement focuses on the Environmental Protection Agency's (EPA) Endocrine Disruptor Screening Program (EDSP) to illustrate how fundamental endocrinology ...

This report provides a state-of-the-art review of available computational models for developmental and reproductive toxicity, including Quantitative Structure-Activity Relationship (QSARs) and related estimation methods such as decision tree approaches and expert systems. At present, there are relatively few models for developmental and reproductive toxicity endpoints, and those available have ...