Coumadin (R-, S-warfarin) is a challenging drug to accurately dose, both initially and for maintenance, because of its narrow therapeutic range and wide interpatient variability and is typically administered as a racemic (Rac) mixture, which complicates the biotransformation pathways. The goal of the current work was to identify the human UDP-glucuronosyltransferases (UGTs) involved in the gluc...

Phosphotriesterase (PTE) from soil bacteria is known for its ability to catalyze the detoxification of organophosphate pesticides and chemical warfare agents. Most of the organophosphate chemical warfare agents are a mixture of two stereoisomers at the phosphorus center, and the S(P)-enantiomers are significantly more toxic than the R(P)-enantiomers. In previous investigations, PTE variants wer...

This study focuses on RR, SS and RS medetomidine (MM) and inclusion of several achiral acids to distinguish which acid can help conglomerate formation instead of crystallizating racemic mixtures by defining the low-lying energy of their structures. Favorable orientation of acids was determined in interaction with the MM enantiomers after optimization. The most noticeable interactions include hy...

In this work, an improved single-column chromatographic (ISCC) separation process is proposed. The term `improved' refers to both conceptual and physical modifications compared to the available single-column processes, including a novel fraction collection scheme and allowing overlapped peaks from adjacent cycles. Also the fraction collection mechanism was modified in order to facilitate online...

The chirality of biopolymers and its emergence from the racemic prebiotic world is one key mysteries science. There are many versions on how total chiral balance breaking occurred, but they all face an insoluble challenge—the impossibility a shift towards formation based only D-sugars L-amino acids. A possible solution to this problem lies in asymmetric autocatalysis crystals. Since reaction he...

The Tröger's base derivative rac - TBPP was synthesized and separated into two enantiomers R 2N S by chiral column chromatography. These compounds show a strong circularly polarized luminescence with g lum values of +0.0021, ?0.0025, respectively. second way to fabricate the -based CPL-active material is co-gel fluorescent ?-glutamic acid gelator DGG co-assembly strategy. At molar ratio / = 1:8...

Enantiomers (2S, 4S)- and (2R, 4R)-3-(naphthalene-1-ylmethyl) pentane-2,4-diols were synthesized by the reduction of (Z)-4-hydroxy-3-(naphthalene-1-ylmethyl) pent-3-en-2-one with NaBH4 in methanol (MeOH). Crystallization dichloromethane this racemic mixture led to simple crystals a crystalline habit similar morphologies; however, group them, it was possible find barely observable difference tha...

A ny object that cannot be superimposed upon its mirror image is said to be chiral, and the two mirror image forms are called enantiomers. A person’s left and right hands are one familiar macroscopic example of chiral objects. Chirality is of immense interest in chemistry, because many organic molecules are chiral. Any atom in a molecule that is tetrahedrally bonded to four different functional...