glycosylation of protected actinamine with "fraudulent" sugars followed by C-3' carbonyl generation (by an elimination reaction) and deprotection. We describe here an alternative method of modification at C-6' by elaboration of an activated intermediate 2 which we have prepared2) in three steps from N,N'-dibenzyloxycarbonylactinamine and 3,4,6-tri-Oacetyl 2 deoxy 2 nitroso ƒ¿ L. glucopyranosyl ...

Es wurde gefunden, dass Tris(pentafluorphenyl)boran die zweifache C(sp3)-H-Silylierung von mehreren Trialkylaminderivaten mit Dihydrosilanen katalysiert und entsprechenden 4-Silapiperidine in annehmbaren Ausbeuten ergibt. Die mehrstufige Reaktionsabfolge beinhaltet Dehydrierung des Amins zum Enamin an zwei Alkylresten elektrophile (eine inter- eine intramolekular) Silylierungen jener Enamine.

Previous studies of the inter—relationships between isocyanide, imine, and carbene ligands on platinum(II), and of the stereochemistries of the latter two ligands will be briefly reviewed. Attempts to use these relationships to prepare platinum—olefin—carbene complexes have been unsuccessful but have led to an interesting ortho—metallated carbene derivative. The insertion of isocyanide into the...

Considering the astounding biomedicine properties of pharmaceutically active drug, 4-aminophenazone, also known as 4-aminoantipyrine, work reported in this manuscript details formation novel cocrystals rearranged 4-aminophenazone and 4-nitro-N-(4-nitrobenzoyl) benzamide 1:1 stoichiometry under employed conditions for thiourea synthesis by exploiting use its amino component. However, detailed an...

The imidazoles 1a-g add to the CC-double bond of the iminium ion 2 with rate constants as predicted by the equation log k = s(N)(N + E). Unfavourable proton shifts from the imidazolium unit to the enamine fragment in the adduct 3 account for the failure of imidazoles to take part in iminium-activated aza-Michael additions to enals.

A concise synthesis of a highly functionalized intermediate lacking only C10 of the mitomycin backbone is described. The key to this development is the Brønsted acid-catalyzed aza-Darzens reaction used to forge the cis-aziridine. Additionally an oxidative ketalization fortuitously occurs during the quinone-enamine coupling step, leading to an orthogonally protected hydroquinone.

Schiff-base macrocycles that combine keto-enamine and enol-imine tautomers within the same ring were synthesized and characterized. These new macrocycles form host-guest complexes with organic cations and unexpectedly form a lyotropic liquid crystal in organic solvents such as chloroform and toluene.

The assembly of complex spirocyclopentaneoxindoles via a novel organocatalytic iminium-enamine cascade process is reported. Reactions between 3-substituted oxindoles and α,β-unsaturated aldehydes catalyzed by second generation prolinol ethers provided the desired products in high yield with excellent levels of enantioselectivity in a single step.