Gastric residence time of oral controlled release system such as microspheres is increase by different techniques such as floating and mucoadhesive system. The objective of present investigation was to formulate floating microspheres of Nateglinide in order to increase gastric residence time, increased bioavailability and to reduce dose frequency of drug molecule. Novel o/w emulsion solvent dif...

Spherical crystallization of drugs is the process of obtaining larger particles by agglomeration during crystallization. The most common techniques used to obtain such particles are spherical agglomeration and quasi-emulsion solvent diffusion. Ammonia diffusion systems and crystallo-co-agglomeration are extensions of these techniques. By controlling process parameters during crystallization, su...

Ellipsoid-shaped nanoclusters composed of single superparamagnetic nanoparticles can be generated by emulsion electrospinning. Stretching and subsequent solvent evaporation of iron oxide loaded emulsion droplets during the emulsion electrospinning process enables the creation of such structures embedded in polymer nanofibers. Dissolution of the polymer fibers yields an aqueous dispersion of the...

While the Stokes-Einstein (SE) equation predicts that the diffusion coefficient of a solute will be inversely proportional to the viscosity of the solvent, this relation is commonly known to fail for solutes, which are the same size or smaller than the solvent. Multiple researchers have reported that for small solutes, the diffusion coefficient is inversely proportional to the viscosity to a fr...

The diffusion behavior of methanol in different critical media (n-pentane, n-hexane, n-heptane and acetone) was investigated by the Monte Carlo (MC) method. From the simulation results, the diffusion constant of methanol molecule in the critical n-hexane is much larger than those in n-pentane, n-heptane and acetone. By analyzing the microscopic configurations of the critical mixtures, it is fou...

Dichloromethane (DCM) and acetonitrile (ACN) are the most commonly used solvents for polylactic acid (PLA) or poly(lactic-co-glycolic acid) (PLGA). In order to select a suitable solvent system for the preparation of PLGA microspheres containing tumor necrosis factor-alpha (TNF-a), the stability of TNF-a when mixed with DCM and ACN under various phase conditions was investigated. When the TNF-a ...

the objective of the present investigation was to design a sustained release floating microcapsules of theophylline using two polymers of different permeability characteristics; eudragit rl 100 (eu rl) and cellulose acetate butyrate (cab) using the oil-in-oil emulsion solvent evaporation method. polymers were used separately and in combination to prepare different microcapsules. the effect of d...

Controlled release systems can modify the rate of drugs and direct them to specific sites action, making more effective and/or reducing adverse effects. The objective this study was investigated, poly(β-hydroxybutyrate) (PHB) poly(ε-caprolactone) (PCL) nanospheres improve delivery Simvastatin (SIM). Nanospheres were prepared by emulsion/evaporation technique solvent, varying amount SIM added. q...