Microsponge containing ketotifen drug with three different proportions of ethyl cellulose and drug were obtained successfully using quasi-emulsion solvent diffusion method. These formulations were studied for particle size and physical characterization. These microsponges enriched gel formulation were prepared by using 2 and 3 % w/w of SCMC and studied for viscosity, pH, gel strength, spreadabi...

Lipids were extracted from Isochrysis galbana using a microwave-assisted method accompanied by various types of organic solvents. The effects of organic solvent type and microwave input energy on the fatty acid characteristics of the extracted lipids and their biodiesel product were investigated. Variations in the characteristics of the lipids extracted using a combination of n-hexane and iso-p...

The aim of this study was to investigate non-solvent precipitation of starch to produce nanoparticles that could be used in Pickering emulsions. The material used was waxy maize, modified with octenyl succinic anhydride. Different methods of non-solvent precipitation were investigated, and a method based on direct mixing of an 8% starch solution and ethanol (ratio 1:1) was found to produce the ...

While the Stokes-Einstein (SE) equation predicts that the diffusion coefficient of a solute will be inversely proportional to the viscosity of the solvent, this relation is commonly known to fail for solutes, which are the same size or smaller than the solvent. Multiple researchers have reported that for small solutes, the diffusion coefficient is inversely proportional to the viscosity to a fr...

OBJECTIVES The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of theophylline using ethylcellulose as the retardant material with high entrapment efficiency. MATERIALS AND METHODS Microspheres were prepared by water-in-oil-in-oil (W/O1/O2) emulsion-solvent diffusion (ESD). A mixed solvent system consisting of acetonitrile and dichloromethane ...

Plasmid DNA was encapsulated within poly(d,l-lactic-co-glycolic acid) (PLGA) nanospheres by using polyethylene glycol (PEG) assisted solubilization technique of plasmid DNA in organic solvents. Plasmid DNA was solubilized in an organic solvent mixture composed of 80% methylene chloride and 20% DMSO by producing PEG/DNA nano-complexes having an average diameter less than 100 nm. DNA could be sol...

Fluorocarbon oil reinforced triple emulsion drops are prepared to encapsulate a broad range of polar and non-polar cargoes in a single platform. In addition, it is demonstrated that the fluorocarbon oil within the emulsion drop acts as an effective diffusion barrier, as well as a non-adhesive layer, enabling highly efficient encapsulation and retention of small molecules and active biomolecules...

Thymol, an important and advantageous component of many essential oils, has been applied as an antimicrobial agent in animals. To increase the duration of action of this compound in ruminants, it was decided here to prepare a controlled release carrier for thymol. Hydroxy propyl methyl cellulose (HPMC) and ethyl cellulose (EC) were used as the matrix polymer here. Mixtures of thymol with eight ...

The classical utilized double emulsion solvent diffusion technique for encapsulating water soluble Mitomycin C (MMC) in PLA nanoparticles suffers from low encapsulation efficiency because of the drug rapid partitioning to the external aqueous phase. In this paper, MMC loaded PLA nanoparticles were prepared by a new single emulsion solvent evaporation method, in which soybean phosphatidylcholine...

Aim of the present study was to characterize the process of atomization and drying of layer-by-layer emulsions containing lecithin (single layer emulsion) and lecithin/chitosan (multilayer emulsion) and the oxidative stability of the spray-dried emulsions during storage. For this purpose, the analysis of the emulsion spray droplet size during atomization by two different atomization devices, i....