BACKGROUND Studies on the effect of inadequate empirical antibiotic therapy on the outcome of patients with systemic infection have led to inconsistent results. METHODS We analysed data from a comprehensive clinical database collected prospectively in a university hospital between 2008 and 2009. All adult patients who registered in the emergency department (ED) with a bloodstream infection (B...

The choice of effective empirical treatment of fever in the neutropenic host requires a sound knowledge of the local microbial epidemiology and the susceptibility patterns of pathogens. Since the list of possible pathogens can, at best, only be narrowed to a few most likely organisms, the use of empirical broad-spectrum antibiotic therapy in such situations is warranted. Indeed, the empirical u...

OBJECTIVES An economic evaluation was performed of empirical antisecretory therapy versus test for Helicobacter pylori in the management of dyspepsia patients presenting in primary care. METHODS A randomized trial in 106 general practices in the County of Funen, Denmark, was designed to include prospective collection of clinical outcome measures and resource utilization data. Dyspepsia patien...

A panel of infectious disease specialists, clinical microbiologists and hospital epidemiologists of the five Swiss university hospitals reviewed the current literature on the treatment of invasive fungal infections in adults and formulated guidelines for the management of patients in Switzerland. For empirical therapy of Candida bloodstream infection, fluconazole is the drug of choice in non-ne...

BACKGROUND The aim of this study was to evaluate the efficiency, adverse effects, and pharmacoeconomic impact of empirical and preemptive antifungal therapy for febrile neutropenic hematological malignancy patients in China. MATERIAL AND METHODS Patients with febrile neutropenia during hematological malignancy were randomly divided into an empirical group and a preemptive group. The preemptive ...

purpose: to report the clinical, confocal scan, and histopathologic features of bilateral nocardia keratitis following photorefractive keratectomy (prk). case report: a 23-year-old girl underwent simultaneous bilateral prk for myopia. on the third postoperative day, dense central infiltrates mainly involving the anterior stroma were noticed in both eyes. clinical and confocal scan features were...

BACKGROUND Empirical combination therapy is recommended for patients with known or suspected Pseudomonas aeruginosa (PA) infection as a means to decrease the likelihood of administering inadequate antimicrobial treatment, to prevent the emergence of resistance, and to achieve a possible additive or even synergistic effect. METHODS We performed a post hoc analysis of patients with PA bloodstre...

just regarding different risk factors for antibiotic resistant uropathogenes, it seems justice to improve diagnostic power for drug resistant uropathogenes and well appropriate empirical therapy. 300 and 145 cases of clinicopathologically diagnosed nosocomial and spinal cord injured (sci) associated urinary tract infection (uti), respectively, were considered as our samples included in our 24 m...

aim and background: recently, “third wave” behavioral and cognitive interventions have received extensive attention between researchers.to evaluation of the efficacy of one of these treatments, acceptance and commitment therapy (act), this study compares this treatment with cognitive - behavioral therapy (cbt) in obsessive- compulsive disorder (ocd).   methods and materials: in this study a qua...