chlorinated biphenyl (PC8I mixtures had been described previously. High mortality, liver damage, and edema were associated with only two of the three PCB5. Using column and gas chromatography, several compounds were identified in the diethylether fracdon of these two PCBs. A chick embryo assay confirmed the high toxicity of this fraction. Mass spectremetric and microcoulometric analyses indicat...

Organisms have evolved complex defense systems against oxidative stress. Bird eggs contain maternally derived antioxidants that protect embryos from oxidative damage. The antioxidant system components are thought to be integrated, but few studies have analyzed the covariation between antioxidant concentrations, embryo 'oxidative status' and morphology. In addition, no study has tested the effec...

HYDATID disease is due to the development in man, acting as an intermediate host, of the cystic larval form of a small tapeworm, Echinococcus granulosus, the normal habitat of which is the ileum of the dog. Ova from an infected dog are deposited with its faeces on the ground. By this means grass and vegetables are polluted with ova, and when eaten by sheep, cattle, goats or occasionally by man ...

We studied the hepatotoxic effects of a deltamethrin containing formulation (Decis®) on developing em-bryo of Gallus domesticus. Fertilized eggs were immersed in three different concentrations of deltamethrin (12.5, 25 and 50 mg/L) for 60 min at 37 ˚C prior to incubation (ED 0) and on the 4th day of incubation (ED 4) and incubated till embryonic day (ED) 16. Exposure to 50 mg/L of deltamethrin ...

Introduction: There is little evidence of potential hepatotoxicity of Remdesivir (RDV), in vitro. Regarding the effective results of RDV in patients with COVID-19 and the impact of COVID-19 on liver function, we investigated the effects of RDV on the expression and activity of liver enzymes in chicken embryo-derived hepatocytes. Material and Methods: In this in vitro study, 20 embryonated chic...

A procedure is described for the isolation of enzymatically active nuclei from chick embryo liver. It consists of the homogenization of the pooled tissue in 0.32 M sucrose-3 mM MgCl(2) followed by a slow centrifugation. The resulting nuclear pellet is then purified further in a discontinuous density gradient composed of sucrose solutions containing Mg(2+) ions, the lower portion of the gradient...

It has been suggested that first embryo cleavage can be related with the embryonic-abembryonic axis at blastocyst stage in mice. Thus, cells of the 2-cell embryo might be already biased to form the inner cell mass or trophectoderm. This study was conducted to observe the possible effects of embryo biopsy on cell allocation patterns during embryo preimplantation in two different mouse strains an...

Interstitial Cajal Cells (ICCs) were only proven in human adult hepatic tissue. The immune phenotypes of various cell types in the human embryonic liver (HEL) are scarcely described. It was hypothesized that in HEL ICCs are present and distinctive to the precursor/progenitor cells populations. It was aimed and performed a qualitative study of HEL by use of antibodies against CD117/c-kit, CD31, ...

1. The development, localization and heterogeneity of acid phosphatase and a Zn(2+)-activated acid phosphatase in cellular fractions of developing chick liver were studied. 2. Acid phosphatase is distributed abundantly in the particulate and soluble fractions. The soluble fraction is rich in Zn(2+)-activated acid phosphatase, which attains its peak activity at about 15 days of incubation. 3. Th...

1. The fate of [(14)C]thalidomide orally administered to pregnant rabbits at the beginning of the sensitive phase of pregnancy has been studied. 2. After the oral administration of [(14)C]thalidomide on the 192nd hour of pregnancy about 68% of the radioactivity appears in the urine and 22% in the faeces. 3. The urinary (14)C is made up as follows (% of dose): thalidomide (2); alpha-(o-carboxybe...